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Effect of peripheral CB 1 receptor antagonist JD5037 in the use of the AMPK-activated agent metformin monotherapy and multipharmacy in a rat model of pulmonary hypertension induced by wild lily

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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Pulmonary hypertension (PH) is a rare disease characterized by an increase in pulmonary artery pressure of more than 25 mmHg at rest, leading to right-sided heart failure and premature death

AMPK is a cellular energy state sensor that senses low cellular adenosine triphosphate (ATP) concentrations (e.

Today, the gold standard for PAH therapy is early combination therapy with compounds that affect different pharmacological targets

The current study evaluated the effect of the peripheral cannabinoid CB 1 receptor antagonist JD5037 for metformin monotherapy and multidrug therapy in rats with wild lily-based induced mild PH

References:

Remiszewski P, Pędzińska-Betiuk A, Mińczuk K, Schlicker E, Klimek J, Dzięcioł J, Malinowska B.

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