EJNMMI: Non-invasive assessment of coronary microvascular dysfunction in type 2 diabetic mouse models using SPECT myocardial perfusion imaging and quantitative myocardial perfusion entropy

Coronary microvascular dysfunction (CMVD) is considered to be the main cause of ischemic heart disease, so cardiovascular mortality has nothing to do with the presence of macrovascular disease

Coronary microvascular dysfunction (CMVD) is considered to be the main factor in the occurrence of ischemic heart disease.

Results: The feasibility study found that dobutamine stress, acute NO synthase and cyclooxygenase inhibition were the best conditions for MPE quantification, and MPE in T2D animals increased significantly (P <0.

Increased blood glucose in T2D mice significantly reduced the left ventricular ejection fraction, LIR partially restored blood glucose and completely prevented LVEF damage, but had no significant effect on capillary density

Figure 1 Flow chart of this research

Figure 1 Flow chart of this research

Figure 2 Experimental protocol for feasibility (F) (A) and therapeutic (T) studies (B)

Figure 2 Experimental protocol for feasibility (F) (A) and therapeutic (T) studies (B)

Figure 3 Schematic diagram steps of MPE automatic quantification

Figure 3 Schematic diagram steps of MPE automatic quantification

Table non-fasting blood glucose and body mass index data

Table non-fasting blood glucose and body mass index data

Figure 3 A representative 201Tl SPECT myocardial perfusion image to study the feasibility and treatment of animals in each experimental group

Figure 3 A representative 201Tl SPECT myocardial perfusion image to study the feasibility and treatment of animals in each experimental group

Figure 4 A feasibility study of the MPE experimental group from two aspects of rest and stress

Figure 4 A feasibility study of the MPE experimental group from two aspects of rest and stress

MPE quantification can be used for preclinical non-invasive evaluation of CMVD

Carabelli A, Canu M, de Fondaumière M, et al.

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Noninvasive assessment of coronary microvascular dysfunction using SPECT myocardial perfusion imaging and myocardial perfusion entropy quantification in a rodent model of type 2 diabetes.


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