EJPS: Researchers have developed new anti-inflammatory drugs.

SEPTEMBER 11, 2020 /--- In a recent study, Halle-Wittenberg, a researcher at Martin LutherAne University's Institute of Pharmaceuticals, et al., developed a method for producing controlled-quality anti-inflammatory drugs.
because the body does not recognize it as a foreign body, they have an advantage over anti-inflammatory drugs such as ibuprofen or bichlorofenic acid.
results were published in the European Journal of Pharmaceutical Sciences.
to imitate nature, " explains Professor Karsten Mäder of the MLU School of Pharmacy.
", these new anti-inflammatory substances are naturally present in the body, such as the inner surface of cells.
when cells die, phosphatidylserine (PS) and other components in the cell membrane are exposed, which provides a signal to the phagocytosis target.
PS also ensures that the inflammatory response is suppressed.
another ingredient called phospholipid phosphatidyl glycelin (PG) also ensures that there is no excessive inflammatory response.
team has now prepared both substances, so they could be used as drugs to treat infarction, arthritis and psoriasis.
(Photo Source: www.pixabay.com) From a medical point of view, both phospholipids are of concern to researchers because the body cannot identify them as foreign, meaning fewer side effects can be expected.
U.S. study, PS is particularly effective for inflammation after a heart attack.
"But preparation is a complex process, " says Mäder.
Halle's team has now developed a simpler and cheaper production process.
phospholipids to form small particles smaller than ten nanometers in size.
makes them easy to filter asepticly.
have also been shown to be harmless to cells and blood components.
, PG particles produced in this way showed reduced inflammatory activity of phagocytosphages under laboratory conditions.
show that phospholipids work well in anti-inflammatory treatments, " said Mäder, a research team.
, however, some clinical trials are needed before natural anti-inflammatory substances can be used in humans.
(bioon.com) Source: Nature as model: Researchers develop novel anti-ingy substance Source: Miriam Elisabeth Klein et al, Phosphatidylserine (PS) and phosphatidylglycerol (PG) enriched mixed micelles (MM): A new nano-drug delivery system with anti-appy potential?, European Journal of Pharmaceutical Sciences (2020). DOI: 10.1016/j.ejps.2020.105451.