eLife: Blocking sugar metabolism or effectively slowing the progression of lung cancer

, July 8, 2020 /PRNewswire/ -- In a study published in the international journaleLife, scientists from institutions such as the Federal Institute of Technology in Lausanne, Switzerland, studied mouse and human cells and found that blocking a pair of sugar-borne proteins could be used as an effective treatment for lung cancerPhoto Credit: Liloon/Julie de Meyer
Cancer cells can use large amounts of sugar to grow and spread quickly, forcing scientists to cut off sugar supplies as a new treatment for cancer, which current research suggests may be an effective treatment, but must be blocked at the same time by blocking multiple pathways to workGlucose transporter ,glucose transporter, which provides sugar to cells, makes it a new target to help researchers develop new ways to starve cancer cells, but researchers don't know the best way, or whether cancer cells switch other sources of energy to grow and spreadresearcher Caroline Contat said: 'Inhibiting the use of sugar in lung tumors may be an effective treatment strategy, but at the moment we don't know whether we can target glucose transporter proteins and which one seisaves specifically.' The researchers then performedgeneticengineering modifications on lung cancer mice to cause them to lose a glucose transporter protein called Glut1 or the alternative sugar transporter glut3, and found that tumors in mice that were missing Glut1 or Glut3 grew as fast astumorsthe body of mice carrying both transport proteinsHowever, when the researchersgeneticmodification sedituated the mice with glut1 and Glut3, the tumors of the mice were less and survived longer, and by using positron emission tomography (PET) imaging and sugar molecules carrying radioactive markers, the researchers confirmed that tumors in the mice used less sugar and slower tumor growthWhen the researchers removed Glut1 and Glut3 from four different human lung cancer cell lines in the lab, they promoted the slow growth oftumors in the mouse body cells, and the results suggested that Glut1 and Glut3 may be the components necessary to promote lung cancer growth by doing imaging studies nano-
, the researchers found that most of the sugar-derived biomass in mouse tumor cells accumulates in a cell cell called lamellar bodies, and glut1 is essential for energy storage Finally, researcher Etienne Meylan said researchers need more research on tumor fuel storage, which may suggest a new treatment for lung cancer that focuses on developing new strategies by targeting the energy use of tumor cells, especially if blocking Glut1 and Glut3 therapies or potentially helping to block the growth of of tumors in the lungs (BioValleyBioon.com) original origins: Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, et al.
Combined li of glut1 and glut3 walks aden lungocarcinoma growth , eLife
(2020) DOI: 10.7554/eLife.53618