End-of-2020 inventory: Nature magazine's breakthrough research!

Although very rigorous de-contamination analysis was used to give up up to 92.3 percent of the total sequence data, the researchers found that these TCGA blood characteristics were still predictive when applied to cancer patients in the Ia-IIc phase or cancer patients without any genomic changes (confirmed by two commercial-grade cellless tumor DNA platforms).
: Breakthrough! For the first time, the tau protein, the culprit of neurodegenerative diseases, is observed moving back and forth between neuron cells! Doi:10.1038/s41586-020-2156-5 In the fight against neurodegenerative diseases such as frontal lobe dementia, tau protein is perhaps the biggest culprit, tau protein is present in brain cells, which maintains the structure and stability of neurons and helps transport nutrients from one part of the cell to another.
When the tau protein folds incorrectly, everything changes, it becomes sticky and insoluble, constantly gathering and forming neurogenic fiber tangles in neurons, disrupting the function of neurons and causing cells to eventually die, or worse, only a relatively small amount of misfolded tau proteins in neuron cells can cause nearby cells to program dysfunctional brain cells to die.
(
) - In a study published in the international journal Nature, scientists from the University of California and other institutions have uncovered the molecular mechanism by which tau protein travels back and forth between neuron cells, revealing not only the spread of tau protein in neurodegenerative diseases that scientists have studied extensively, but also to provide new ideas and hopes for effectively controlling the production of pathological tau protein.
researcher Kosik says the mechanism by which tau protein travels back and forth between cells may provide a clue to help us develop new ways to effectively block the spread of tau protein, an essential "player" in the tau protein's back-and-forth journey, a low-density lipoprotein called LRP1 (lowy lipoprotein receptor-protein 1), which is located on the membrane of the brain cell and is primarily involved in a variety of body biological processes, as well as helping neurons to ingest cholesterol.
photo Source: ifpnews.com .6 Nature: Scientists have successfully mapped a "functional blueprint" for multiple cancer-causing mutations in a single cancer gene doi:10.1038/s41586-020-020 2175-2 In a recent study published in the international journal Nature entitled "Landscape and function of multiple mutations within the individual oncogenes", scientists from japan's National Cancer Institute and other institutions used research to map and analyze the function of multiple mutations in a single cancer gene.
there have been sporadic reports of cancer cases caused by multiple drive mutations (MMs, multiple driver mutations) in the same cancer gene, but researchers don't know the blueprint for multiple drive mutations and how they are related. In the
study, researchers analyzed 60,954 cancer samples and found 14 cancer-specific cancer genes of all cancer and six cancer types, where the incidence of multiple drive mutations was higher than expected, meaning that MMs were found in at least 9 percent of those genes that carried at least one gene mutation.
: Chinese scientists have revealed the structure of THE SARS-CoV-2 main protease and found that its inhibitor doi:10.1038/s41586-020-2223-y A new coronavirus (SARS-CoV-2) has been identified as COVID-19 virus, which caused the global coVID-19 epidemic in early 2020.
but there are no targeted treatments, and effective treatment options are still very limited.
To quickly identify pilot compounds for clinical use, researchers from Shanghai University of Science and Technology and others have teamed up to launch a joint structurally assisted drug design, virtual drug screening, and high-flunsuct screening project to identify new drug predicates for coVID-19 virus master protease (Mpro), the study was published in the journal Nature.
Mpro is a key SARS-CoV-2 enzyme that plays a key role in mediating virus replication and transcription and is an attractive drug target for the virus.
, the researchers identified a computer-based inhibitor, N3, through computer-aided drug design, and then determined the crystal structure of the COVID-19 virus Mpro.
: Identifying targets for new T-cell immunotherapy is expected to help develop new treatments to fight cancer and autoimmune diseases doi:10.1038/s41586-020-2246-4 A recent study published in the international journal Nature entitled "CRISPR screen in regulatory T cells reveals modul In the study, scientists from the University of California and other institutions said foxp3, one of the key transcription factors that control the development and function of Treg cells ( regulatory T cells ) , is an important advance in Treg immunobiology and opens a door for scientists to learn more about the function and mechanism of Action .
Treg cells are the key cells needed to control the body's immune response and maintain the body's balance, and they are also an important barrier to the body's anti-tumor immunity. Lack of and access to inflammatory properties; a comprehensive and in-depth understanding of the pathfractors that regulate Foxp3 factors may help researchers develop more effective Treg therapies to treat a variety of autoimmune diseases and cancers, and the use of new functional genetic tools can systematically analyze gene regulators that regulate Foxp3 expression.
9 Nature: Heavy! Scientists have revealed for the first time the molecular process by which human bodies make triglycerides! Doi:10.1038/s41586-020-2280-2 Doctors often remind patients that higher levels of triglycerides, a major dietary fat, increase the risk of heart disease, diabetes, obesity, and fatty liver, so researchers are interested in finding new ways to effectively regulate triglyceride levels in the body's blood to control this common disease that can endanger the body's life.
In a recent study published in the international journal Nature, scientists from the Baylor School of Medicine and others revealed the 3D structure and action of diglyceride O-ayl transferase-1 (DGAT1), an enzyme that helps synthesize triglycerides, which are important for the absorption and storage of dietary fat in humans;