Eur J Endocrinol: Early preventive use of levothyroxine in patients with Graves' hyperthyroidism after radioactive iodine therapy can improve their quality of life 

When patients with hyperthyroidism euthyrox only as anti-thyroid drugs adjuvant aim preventive anti-thyroid drug overdose due to hypothyroidism , which can prevent rapid fluctuations in vivo thyroxine

Purpose: Graves disease is often treated with radioactive iodine, but long-term clinical hypothyroidism may produce a series of symptoms, leading to a decline in the quality of life (QoL) of patients

Methods: A multi-center, prospective, open randomized controlled study was used to enroll 94 patients with Graves hyperthyroidism and randomly divided into experimental group (n=46) (group A: early preventive use of LT4 treatment) and control group (n=46) =48) (Group B: standard follow-up)

Results: The primary end point was reached at 6 months: the mental synthesis vector (MCS) of the A group scale 36 (SF-36) was significantly higher than that of the B group (P = 0.

Table: The effect of early LT4 administration on the quality of life after 6 months (multivariate analysis)

Figure 1 The changes of SF-36 psychological comprehensive scores of the two groups over time, the difference was statistically significant at 6 months

Figure 2 Comparison of quality of life scores between early prevention of LT-4 (A1) and standard follow-up (B1) without LT4

Early administration of levothyroxine after radioactive iodine (RAI) is beneficial to the patient's quality of life

Original source:

Taïeb D, Bournaud C, Eberle MC,Quality of life, Clinical outcomes and safety of early prophylactic levothyroxine administration in patients with Graves' hyperthyroidism undergoing radioiodine therapy: a randomized controlled study .

Clinical outcomes and safety of early prophylactic levothyroxine administration in patients with Graves' hyperthyroidism undergoing radioiodine therapy: a randomized controlled study

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