European Radiology: Defining the relationship between idiopathic inflammatory myopathy and specific autoantibodies from an imaging perspective

Idiopathic inflammatory myopathies (IIMs) are a group of rare, heterogeneous multisystem autoimmune diseases characterized by involvement of skeletal muscle, skin, and other organs .
Interstitial lung disease (ILD) is one of the most common manifestations of extramuscular IIM involvement .

Idiopathic inflammatory myopathies (IIMs) are a group of rare, heterogeneous multisystem autoimmune diseases characterized by involvement of skeletal muscle, skin, and other organs .

Interstitial lung disease (ILD) is one of the most common manifestations of extramuscular IIM involvement .

Although lung biopsy is rarely performed for ILD in IIM , nonspecific interstitial pneumonia (NSIP) is an important way to obtain a histopathological pattern that can also show the presence of diffuse alveolar damage (DAD) and organizing pneumonia (OP) .

and range .
On high-resolution computed tomography (CT), bilateral reticular formation and ground-glass density are the most common features of myositis-related ILD, but areas that appear to be consolidation are also present .

Although lung biopsy is rarely performed for ILD in IIM , nonspecific interstitial pneumonia (NSIP) is an important way to obtain a histopathological pattern that can also show the presence of diffuse alveolar damage (DAD) and organizing pneumonia (OP) .
and range .
On high-resolution computed tomography (CT), bilateral reticular formation and ground-glass density are the most common features of myositis-related ILD, but areas that appear to be consolidation are also present .
To our knowledge, so far, no researchers have performed a specific analysis of different CT-ILD outcomes and their association with different IIM subgroups .

Recently, a study published in the journal European Radiology identified different CT-ILD patterns by analyzing different CT appearances and their potential relationship with different IIMs and MSAs, and assessed the availability of radiologists for the recognition of these patterns.

Repeatability .
 

Recently, a study published in the journal European Radiology identified different CT-ILD patterns by analyzing different CT appearances and their potential relationship with different IIMs and MSAs, and assessed the availability of radiologists for the recognition of these patterns.
Repeatability .
 

All consecutive IIM patients (2003-2019) were analyzed in this study

Of the 257 IIM patients, 94 (36.
6%) had ILD; of these, 87 (93%) were MSA-positive

Figure 30-year-old woman, a Axial and b sagittal thin-section CT images show a subpleural lung cyst with some small areas of ground-glass density .

c Axial thin -section CT image of a 58-year-old woman showing bilateral subpleural honeycomb changes .
 

Figure 30-year-old woman, a Axial and b sagittal thin-section CT images show a subpleural lung cyst with some small areas of ground-glass density .
c Axial thin -section CT image of a 58-year-old woman showing bilateral subpleural honeycomb changes .
 Figure 30-year-old woman, a Axial and b sagittal thin-section CT images show a subpleural lung cyst with some small areas of ground-glass density .
c Axial thin -section CT image of a 58-year-old woman showing bilateral subpleural honeycomb changes .
 

In conclusion, the heterogeneity of ILD shown in IIM patients can be divided into three groups by CT appearance .

CT findings clearly correlated with MSA as determined by radiologists , with good intra-observer repeatability and inter-measurer reliability .

In conclusion, the heterogeneity of ILD shown in IIM patients can be divided into three groups by CT appearance .
CT findings clearly correlated with MSA as determined by radiologists , with good intra-observer repeatability and inter-measurer reliability .

Original source :

Original source :

Amandine Laporte , Kubéraka Mariampillai , Yves Allenbach , et al .

Idiopathic inflammatory myopathies: CT characteristics of interstitial lung disease and their association(s) with myositis-specific autoantibodies.
DOI: 10.
1007/s00330-021-08411-w

Amandine Laporte Kubéraka Mariampillai Yves Allenbach ,et al 10.
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