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Bone marrow (BM) damage caused by chemotherapy is an important cause of the morbidity and mortality of acute myeloid leukemia (AML)
.
The findings in many studies of
leukemia suggest that lymphocyte subsets may play a role in the recovery of hematopoiesis after AML chemotherapy, but how the lymphocyte subsets are affected by intensive chemotherapy is still unknown .
Here, the foreign research team evaluated the resuscitation immunity after regenerative BM induction chemotherapy (17 days) and related blood AML, which evaluated the innate and adaptive immune subsets .
Figure 1: The composition of BM immune subgroups after AML recovery after intensive chemotherapy The composition of BM immune subgroups after recovery after AML intensive chemotherapy Figure 2: The frequency of CD4CM T and NK cells is related to the recovery of neutrophils after AML chemotherapy
.
Figure 2: The frequency of CD4CM T and NK cells is related to the recovery of neutrophils after AML chemotherapy
.
The NK/CD4CM ratio in the BM after chemotherapy was significantly correlated with the subsequent recovery time of neutrophils (Spearman's ρ = -0.
723, p <0.
001, FDR <0.
01)
.
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.
The findings in many studies of
leukemia suggest that lymphocyte subsets may play a role in the recovery of hematopoiesis after AML chemotherapy, but how the lymphocyte subsets are affected by intensive chemotherapy is still unknown .
Here, the foreign research team evaluated the resuscitation immunity after regenerative BM induction chemotherapy (17 days) and related blood AML, which evaluated the innate and adaptive immune subsets .
Figure 1: The composition of BM immune subgroups after AML recovery after intensive chemotherapy The composition of BM immune subgroups after recovery after AML intensive chemotherapy Figure 2: The frequency of CD4CM T and NK cells is related to the recovery of neutrophils after AML chemotherapy
.
Figure 2: The frequency of CD4CM T and NK cells is related to the recovery of neutrophils after AML chemotherapy
.
The NK/CD4CM ratio in the BM after chemotherapy was significantly correlated with the subsequent recovery time of neutrophils (Spearman's ρ = -0.
723, p <0.
001, FDR <0.
01)
.
Leave a message here
