Experts commented that Cell Stem Cell Xie Cen / He Shijun and others collaborated to discover a new evidence of "liver treatment of intestinal diseases" - the liver bile acid metabolism axis regulates the repair of intestinal epithelial damage

Reviews | Liejun Guo (Rutgers University), Wei Jia (Hong Kong Baptist University, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University)

Editor-in-charge |

Leucine-rich repetitive G protein-coupled receptor 5 (Lgr5) is a surface marker of ISCs, which are mainly distributed at the base of the crypt and maintain the normal function

Finally, the researchers applied the FXR agonist Obecholic acid (there is currently no CYP8B1-specific inhibitor) to inhibit CYP8B1 expression, and found that it could restore Lgr5⁺ ISCs activity and effectively improve enteritis, further demonstrating the important role of

In summary, the study elucidated the new mechanism of liver bile acid metabolism enzyme CYP8B1 and its product CA involved in the progression of intestinal inflammation, identified the metabolic signaling molecule CA for cross-organ communication, and proposed a new idea

https://doi.

Model Maker: Eleven

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