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Next-day fasting (ADF) is a new dietary therapy that can reduce weight and improve blood lipid abnormalities, but the effects of this diet on patients with non-alcoholic fatty liver disease (NAFLD) are still unknown.
study, which aims to assess the effects of ADF on weight and blood lipids in patients with non-alcoholic fatty liver disease, was published online at BMC Gastroenterol.
271 NAFLD patients were randomly divided into ADF, limited-time eating (TRF) or control groups for 12 weeks.
(weight, fat quality/fat-free mass) and an enzymatic analysis of plasma lipids.
results showed that the weight of the ADF group decreased significantly by 4.56±0.41 kg (6.1±0.5%) and that the TRF group lost 3.62±0.65 kg (4.83±0.5) over a four-week period. 9%), the weight loss was even greater in the two groups after 12 weeks (ADF: - 4.04±0.54 kg, 5.4±0.7%; TRF: - 3.25±0.67 kg, 4.3±0.9%).
ADF group (- 3.49±0.37 kg; 11±1.2%) and TRF group (- 2.91±0.41 kg; 9 .6±1.3%) decreased significantly in fat, with the ADF group further reducing fat after 12 weeks (- 3.48±0.38 kg; 11±1.2%).
total cholesterol in the ADF group decreased significantly at both points in time (-0.91 ±0.07 mmol/L; 18.5 ±1.5%) compared to the control group and the TRF group.
ADF group (- 0.64 ± 0.06 mmol/L; 25 ± 1.9%) and TRF group (0.58 ± ± 0.07 mmol/L;20 ±1.7%) was significantly reduced at 12 weeks.
changes in fat quality, HDL, LDL, peritutation insulin, blood sugar, liver stiffness, systolic pressure, or espressopressuration did not vary significantly between the groups.
, the results suggest that ADF appears to be an effective dietary therapy that can reduce weight and improve blood lipid abnormalities in a relatively short period of time (4 to 12 weeks) for patients with non-alcoholic fatty liver disease.
ADF's potential preventive effects on cardiovascular disease need to be confirmed by further research.
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