For the first time, Chinese scientists have revealed a panoramic view of lung adenocarcinoma molecules

Shanghai, July 10 (Reporter Yan Weiwei) Lung cancer is China and the world's highest morbidity and mortality of malignant tumors, of which lung adenocarcinoma is the main pathological type of non-small cell lung cancer, accounting for about half of all lung cancer. On July 9th Cell, the world's top academic journal, published a large-scale sketch of the proteomics of clinical pulmonary adenocarcinoma, completed by Chinese scientists. According to the academic circles, the first large-scale and systematic construction of pulmonary adenocarcinoma protein panorama and molecular subtype characteristics, revealing the molecular characteristics of Chinese pulmonary adenocarcinoma and potential prognosis and diagnosis and treatment of biomarkers, for the precision medical treatment of lung adenocarcinoma provides important resources and clues.
protein is the direct performer of all life functions and is the target of almost all drugs. Proteomics has gradually become one of the core contents of biomedical research. In this study, the
team of Tan Minjia researchers from The Shanghai Institute of Medicine in China joined forces with the military
Military Medical Research Institute, the National Protein Science Center (Beijing) He Fuchu
team, the Wang Yi Researcher Team, the National Cancer Center/China Medical
Oncology Hospital Cheng Shuxuan
, Xiaoting researcher team, Professor Li Wei of Shanghai Jiaotong University and other teams, the first time in the world to lung adenocarcinoma large-scale, high-volume, systematic panoramic proteomics research, and strive to map the pulmonary molecular map of pulmonary adenocarcinoma population through panorama, in-depth understanding of the pathological mechanism of pulmonary adenocarcinoma.
research carried out in-depth analysis of protein expression spectrum and phosphorylation modified after translation of pulmonary adenocarcinoma and cancer sideline tissue in 103 clinical patients Chinese, and for the first time, the molecular map of pulmonary adenocarcinoma was described from the protein level system, and the molecular characteristics closely related to the patient's prognostics were found, especially the protein molecular characteristics of the two main genes of pulmonary adenocarcinoma (TP53 and EGFR) mutation populations were found.
used proteomic expression spectrum data to divide lung adenocarcinoma into three proteomic subsypes. Among them, type I. is closely related to cell metabolism and tumor microencology, clinical information shows that the type is mainly in the early clinical population, the prognostication is the best; Combined with phosphorylation modification spectrum data analysis, the study also revealed the characteristics of kinase activity between different subsypope groups, providing a basis for more accurate characterization and treatment of lung adenocarcinoma. The study also screened 27 potential prognostic markers for pulmonary adenocarcinoma with serological testing value and several potential drug targets for pulmonary adenocarcinoma and its specific mutation subsype. The protein concentration was found to be closely related to the poor prognosis of lung adenocarcinoma by confirming the plasma samples of a larger independent population of the representative marker HSP 90beta. These results provide important scientific clues and theoretical support for the analysis, accurate diagnosis and treatment of pathological mechanisms of lung adenocarcinoma.