For the first time, chinese scientists have revealed a panoramic view of the molecules of lung adenocarcinoma.

This article is reprinted from Guangming Daily.lung cancer is the highest incidence rate and mortality rate in China and the world. Lung adenocarcinoma is the main pathological type of non-small cell lung cancer, accounting for about half of all lung cancer.on July 9, the international top academic journal "cell" published a large-scale clinical lung adenocarcinoma proteome sketch work completed by Chinese scientists.according to the academic community, this work is the first large-scale and systematic construction of the protein panorama and molecular subtype characteristics of lung adenocarcinoma, revealing the molecular characteristics and potential prognostic and diagnostic biomarkers of lung adenocarcinoma in China, which provides important resources and clues for the precise medical treatment of lung adenocarcinoma.protein is the direct executor of all life functions, and almost the target of all drugs.proteomics has gradually become one of the core contents of biomedical research.in this study, the research team of Tan Minjia, Shanghai Institute of medicine, Chinese Academy of Sciences, together with Academician he Fuchu and Wang Yi from Academy of military medicine, National Center for Protein Science (Beijing), National Cancer Center / Chinese Academy of Medical Sciences Cancer Hospital Cheng Shujun and Xiao Ting, and Professor Li Jing of Shanghai Jiaotong University The team, for the first time in the world, has carried out a large-scale, high-throughput and systematic panoramic proteomics study on lung adenocarcinoma, striving to draw a panoramic protein molecular map of lung adenocarcinoma population, and deeply understand the pathological mechanism of lung adenocarcinoma.in this study, protein expression profiles and phosphorylation post-translational modification profiles of lung adenocarcinoma and paracancerous tissues from 103 clinical patients were analyzed in depth. For the first time, the molecular map of lung adenocarcinoma was described from the protein level system, and the molecular characteristics closely related to the prognosis of patients were found, especially the mutation population of two major genes (TP53 and EGFR) of lung adenocarcinoma in Chinese population was found The protein molecular characteristics of.the researchers used proteome expression profile data to classify lung adenocarcinoma into three proteomic subtypes.among them, type I is closely related to cell metabolism and tumor microenvironment. Clinical information shows that this type is mainly early clinical population, with the best prognosis; type III is closely related to cell homeostasis and proliferation, mainly in the middle and late clinical stage, showing the characteristics of low tumor differentiation and high gene mutation load; type II is the transitional state of type I and type III.combined with the data analysis of phosphorylation modification spectrum, this study also revealed the characteristics of kinase activity among different subtype populations, providing a basis for more accurate classification and treatment of lung adenocarcinoma.the study also screened 27 potential prognostic markers of lung adenocarcinoma with serological detection value and several potential drug targets for lung adenocarcinoma and its specific mutation subtypes.the protein concentration of HSP 90beta is closely related to the poor prognosis of lung adenocarcinoma.these results provide important scientific clues and theoretical support for the pathological mechanism analysis, accurate diagnosis and treatment of lung adenocarcinoma.end in the past, we chose to watch nature: "naked mole rats riding the wind and breaking the waves" are not afraid of cancer because of this "super ability"? 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