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Front Oncol: Neural invasion is a prognostic indicator of node-negative colon cancer rather than a predictor of adjuvant chemotherapy

 Last Update: 2021-11-11
 Source: Internet
 Author: User

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Colon cancer is one of the common malignant tumors

Research Screening 2010 Nian 1 Yue 1 to 2015 Nian 12 Yue 31 the date SEER database registered in diagnosis for the patients with colon cancer

A total of 57255 patients with lymph node-negative colon cancer who met the inclusion and exclusion criteria were extracted from the SEER database .

The study compared the different demographic and clinical characteristics of patients in the PNI(-) group and PNI(+) group

Survival analysis showed that in stage I colon cancer, the 5-year tumor-specific survival (CSS) rate of PNI(+) patients was 93.

Multivariate survival analysis showed that after adjusting for other prognostic factors , for patients with stage I colon cancer, patients with PNI(+) had a 59% higher risk of tumor-specific death than patients with PNI(-) (HR = 1.

The study further studies the predictive effect of PNI(+) on adjuvant chemotherapy in patients with stage II colon cancer

In multivariate analysis, patients who received adjuvant chemotherapy were not T3 stage colon cancer without nerve infiltration (PNI(-)) (HR = 0.

Among patients with T4 PNI(-) colon cancer, the 5-year CSS rate of patients who received adjuvant chemotherapy was higher than that of patients who did not receive adjuvant chemotherapy, which were 80.
1% and 71.
2%, respectively, and the difference was statistically significant (P <0.
0001); similarly, Among patients with T4 stage PNI(+) colon cancer, the 5-year CSS rate of patients who received adjuvant chemotherapy was higher than that of patients who did not receive adjuvant chemotherapy, which were 73.
3% and 62.
7%, respectively, and the difference was statistically significant (P = 0.
001)
.
Among patients with T4 PNI(-) colon cancer, the 5-year CSS rate of patients who received adjuvant chemotherapy was higher than that of patients who did not receive adjuvant chemotherapy, which were 80.
1% and 71.
2%, respectively, and the difference was statistically significant (P <0.
0001); similarly, Among patients with T4 stage PNI(+) colon cancer, the 5-year CSS rate of patients who received adjuvant chemotherapy was higher than that of patients who did not receive adjuvant chemotherapy, which were 73.
3% and 62.
7%, respectively, and the difference was statistically significant (P = 0.
001)
.

Whether or not chemotherapy affects CSS in T4 patients

T4 patients with or without chemotherapy affect CSS in T4 patients with or without chemotherapy affect CSS in T4 patients with or without chemotherapy affect CSS

Multivariate survival analysis showed that after adjusting for other prognostic factors, for patients with T4 stage PNI(-) colon cancer, patients who received chemotherapy had a 34% lower risk of tumor-specific death than patients who did not receive chemotherapy (HR = 0.
660, 95%CI = 0.
559–0.
779, P <0.
001)
.
For patients with T4 stage PNI(+) colon cancer, the risk of tumor-specific death was 36.
0% lower in patients who received chemotherapy than patients who did not (HR = 0.
640, 95%CI = 0.
438–0.
935, P = 0.
021)
.

Prognostic factors related to T4 patients

Factors related to the prognosis of T4 patients

In summary, studies have shown that positive nerve invasion (PNI) is a poor prognostic indicator for patients with stage I and II colon cancer
.
However, it is a predictor of adjuvant chemotherapy for patients with undead lymph node-negative colon cancer
.
In summary, studies have shown that positive nerve invasion studies have shown that positive nerve invasion studies have shown that positive nerve invasion (PNI) is a poor prognostic indicator for patients with stage I and II colon cancer
.
However, it is a predictor of adjuvant chemotherapy for patients with undead lymph node-negative colon cancer
.
(PNI) is a poor prognostic indicator for patients with stage I and II colon cancer
.
However, it is a predictor of adjuvant chemotherapy for patients with undead lymph node-negative colon cancer
.

Original source:

Tu J, Yao Z, Wu W, Ju J, Xu Y and Liu Y (2021) Perineural Invasion Is a Strong Prognostic Factor but Not a Predictive Factor of Response to Adjuvant Chemotherapy in Node- Negative Colon Cancer.
Front.
Oncol.
11: 663154.
doi: 10.
3389/fonc.
2021.
663154

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