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Colorectal cancer (CRC) is a common malignant tumor
Colorectal cancer (CRC) is a common malignant tumor
The study is a retrospective, multi-center longitudinal cohort study that included patients with stage I-III CRC who had not received neoadjuvant therapy and had undergone radical resection
The study is a retrospective, multi-center longitudinal cohort study that included patients with stage I-III CRC who had not received neoadjuvant therapy and had undergone radical resection
A total of 710 patients were included in the preliminary analysis
1 month before surgery (CEA pre-m1), 1 month after surgery (CEA post-m1), 2-3 months (CEA post-m2-3), 4-6 months (CEA post-m4-6) ) The median (IQR) of serum CEA levels were 3.
1 month before surgery (CEA pre-m1), 1 month after surgery (CEA post-m1), 2-3 months (CEA post-m2-3), 4-6 months (CEA post-m4-6) The risk ratios (HR) of patients with elevated CEA levels were 1.
Subsequently, the adjusted multivariate Cox proportional hazard regression analysis showed that in the preliminary analysis population, CEA elevation (CEA post-m2–3) after 2-3 months after surgery, instead of the other three groups, is an independent risk of recurrence Factors, but has no effect on the OS
Subsequently, the adjusted multivariate Cox proportional hazard regression analysis showed that in the preliminary analysis population, CEA elevation (CEA post-m2–3) after 2-3 months after surgery, instead of the other three groups, is an independent risk of recurrence Factors, but has no effect on the OS
The cumulative recurrence rate of patients with normal CEA and elevated CEA at different time points in the perioperative period was compared
There was a significant difference in RFS between patients with normal CEA and elevated CEA 2-3 months after surgery (n = 266; HR, 2.
There was a significant difference in RFS between patients with normal CEA and elevated CEA 2-3 months after surgery (n = 266; HR, 2.
In summary, studies have shown that postoperative CEA in patients with stage II CRC has prognostic value, especially 2-3 months after surgery is the best detection time point
In summary, studies have shown that postoperative CEA in patients with stage II CRC has prognostic value, especially 2-3 months after surgery is the best detection time point
Original source:
Original source:Li Z, Zhang D, Pang X, Yan S, Lei M, Cheng X, Song Q, Cai L, Wang Z and You D (2021) Association Between Serum Carcinoembryonic Antigen Levels at Different Perioperative Time Points and Colorectal Cancer Outcomes.
Li Z, Zhang D, Pang X, Yan S, Lei M, Cheng X, Song Q, Cai L, Wang Z and You D (2021) Association Between Serum Carcinoembryonic Antigen Levels at Different Perioperative Time Points and Colorectal Cancer Outcomes.
Front.
Oncol.
11:722883.
doi: 10.
3389/fonc.
2021.
722883
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