Gastric Cancer: CDX2, GPA33 and LI-calcium bonded protein expression levels associated with good prognosis in gastric cancer patients

BACKGROUND: Gastric cancer is the fifth most common cancer and the third leading cause of cancer mortality worldwideCDX2 is a prognostic acid marker for intestinal differentiation in gastric cancer, and also transcribes the expression of glycoprotein A33 (GPA33) and hepatic calcium viscoprotein (LI-cadherin), so this study aims to explore the role of intestinal differentiation markers in predicting the prognosis of stomach cancermethod: This study carried out CDX2 and its target GPA33 and LI-calcin combination expression of clinical significance in gastric cancer by analyzing and evaluating the chemical method of multi-immune tissue chemistry based on fluorescenceIn addition, publicly available RNA-seq expression data from 354 gastric cancer samples from the TCGA database were used to verify immunohistization resultsresults: the prognosis of gastric cancer was highly correlated with the expression of three markers (CDX2, GPA33, and LI-calcium-adhesive protein), and regardless of the method used, low or negative protein expression levels in the intestinal differentiation group were associated with the ability to determine the patient's total survivalconclusions: The expression of intestinal differentiation markers CDX2, GPA33 and LI-calcium adhesive proteins was associated with the prognosis of gastric cancer patients