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    Home > Active Ingredient News > Digestive System Information > Gastric Cancer: Propranolol can inhibit the growth of gastric cancer cells by regulating cell proliferation and apoptosis

    Gastric Cancer: Propranolol can inhibit the growth of gastric cancer cells by regulating cell proliferation and apoptosis

    • Last Update: 2021-04-13
    • Source: Internet
    • Author: User
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    Gastric cancer is one of the most common malignant tumors in the world, and it is also the leading cause of death related to cancer.


    Gastric cancer is one of the most common malignant tumors in the world, and it is also the leading cause of death related to cancer.


     

    β-Adrenergic receptors (β-ARs) are G protein-coupled receptors activated by catecholamines (especially norepinephrine and epinephrine).


    Blood vessel

    Propranolol is a non-selective beta-blocker, widely used to treat hypertension, arrhythmia and angina pectoris.


    Recent studies have shown that propranolol has anti-proliferative effects and has anti-angiogenic effects in various cancers.


    The results of the study showed that propranolol can inhibit tumor growth in two cell lines and induce cell cycle arrest and apoptosis in G1 phase.


    immunity

    Figure: The effect of propranolol on cancer cells

    This study confirmed that propranolol inhibits the proliferation of gastric cancer cells by inducing cell cycle arrest and apoptosis in G1 phase.


    This study confirmed that propranolol inhibits the proliferation of gastric cancer cells by inducing cell cycle arrest and apoptosis in G1 phase.


    Metz Medical reminds everyone that the current research is only a basic research, not a clinical trial.


    In recent years, there has been a prospective clinical trial combining propranolol with pembrolizumab as the first-line treatment for patients with metastatic melanoma.


    However, the therapeutic effect of propranolol on tumors is still being explored.


    However, the editor of Metz Medicine believes that propranolol has the effects of lowering heart rate, stabilizing mood, etc.


    Original source:

    Masahiro Koh.


    springer.


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