Gastroenterology: Insulin-like growth factor 1 levels in circulation and colorectal cancer risk

There was a contradiction between the correlation between insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3) levels and colorectal cancer risk in the cycle, and researchers recently conducted complementary serological and Mendel randomization (MR) analyses to determine the relationship between iGF1 or IGF3 cyclogenous levels and colorectal cancer risk2006-2010, researchers collected blood samples from 397,380 participants in the BIOBank study for serum IGF1 levelsThe participants' cancer death data were determined by linking to the National Cancer and Death Registry datamedian follow-up for 7.1 years, with a total of 2665 cases of colorectal tumors recordedIn the multivariate correction model, the IGF1 cycling level was associated with the risk of colorectal cancer (for every additional standard deviation of IGF1 content, the risk ratio was 1.11)In the MR analysis, the standard deviation of 1 standard deviation in IGF1 levels predicted based on genetic factors was associated with a higher risk of colorectal cancer (ratio 1.08)The level of IGFBP3 predicted based on genetic factors was associated with the risk of colorectal cancer (the ratio of the increase in each standard deviation was 1.12)The risk of colorectal cancer was only associated with one variant in the IGFBP3 gene (rs11177526), which was associated with human characteristics and the level of iGF2 circulationby analysing blood samples from nearly 400,000 participants at Biobank, researchers confirmed a link between IGF1 levels in circulation and colorectal cancer