Gastroenterology: Pancreatic catheter adenocarcinoma needs to be alert to venous thrombosis
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Statistics found that the incidence of vein thromboembolism (VTE) was highest in patients with pancreatic catheter adenocarcinoma (PDAC)However, the risk factors and prognosis of VTE in PDAC patients were inadequaterecently, researchers collected data from the BaCAP study in France from May 2014 to November 2018, which included baseline tests, clinical follow-up periods or complications for 731 PDAC patientsThe main endpoint of the study was the occurrence of VTE during follow-upThe secondary endpoint is the progression-free survival rate (PFS) and the total survival rate (OS) time152 patients (20.79%) showed VTE in 19.3 months of median follow-upThe median time from PDAC diagnosis to VTE onset was 4.49 monthsAt 3 months, the cumulative incidence of VTE was 8.07 per cent and 19.21 per cent in 12 monthsIn multivariate analysis, PDAC primary tumor location (Gorge vs Head: Hazard ratio:2.06) and staging (local late vs removable or edge: HR: 1.66; metastasis removable or marginality: HR, 2.50) are independent risk factors for VTE incidencePFS (HR:1.74) and OS (HR:2.02) were shortened in patients with VTE in follow-upstudies have concluded that early onset of venous thromboembolism after pancreatic catheterglinoma is broken or that frequent occurrence swells lead to poor prognosis in patients, and studies are needed to determine whether VTE primary prevention in PDAC patients will improve VTE-related morbidity and mortality
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