Gastroenterology: Study on Genetic Risk Factors Associated with Early Primary Colon Cancer

The incidence of early-ontoe colorectal cancer (CRC in people under 50 years of age) has been on the rise in recent years, but prevention of early-onsis CRC is a problem for people without CRC family historyRecently, researchers looked at the predictive effect of the multigene risk score (PRS) based on 95 CRC-related common genetic risk variants on early onset CRC riskthe study recruited 12,197 participants under the age of 50 and 95,865 participants aged 50 or older, and as of January 2019, in a large-scale genome-related study, PRS was calculated based on CRC-related single nucleotide polymorphism, and an independent queue of 72,573 participants was recruited to verify itthe prS score was significantly correlated with the risk of early-onset CRC for each additional standard deviation in PRS scores, and was more correlated than normal CRC (P for interaction0.01)When the researchers compared the one-quarter of the people with the highest PRS scores with the lowest quarter, the risk of early-onset CRC increased by 3.7 times, while the risk of late-onset CRC increased by 2.9 timesThis association is strongest among participants without CRC-level family history (interaction P s 5.61 x 10-5)For people without CRC family history, the risk of early primary CRC in the highest quarter was 4.3 times higher than in the lowest population, while the risk of late-oncdCRC increased by 2.9 timesstudy found that the cumulative burden of CRC-related common genetic variants is an important factor in early-onsis colon cancer, especially in people without CRC family history