Gastroenterology: The gut microbiome can also change significantly in patients with cirrhosis.

Background is associated with changes in the composition of the target liver cirrhosis and the gut microbiome.
although acute episodes of chronic liver failure (ACLF) are the most serious clinical stage of cirrhosis, there is currently a lack of research in the academic community using quantitative macrogenomics to study changes in the gut microbiome in ACLF.
, this study aims to explore this.
method researchers looked forward to collecting stool samples from 182 patients with cirrhosis.
the microbial composition of a patient's stool sample using the construction and sequencing of a DNA library.
microbial genes are grouped into clusters and presented in the form of macrogenome species (MGS).
results were associated with significant reductions in gene and MGS richness compared to healthy subjects.
loss of this richness is associated with the stage of the disease, which is particularly pronounced in ACLF patients and persists after adjusting for antibiotic treatment.
ACLF was associated with a significant increase in enterococcal bacteria.
changes in the gut microbiome were associated with late-stage liver disease (MELD) and Child-Pugh scores, as well as organ failure, and, in particular, liver encephalopathy and infection.
interesting is that the gut microbiome is an effective predictor of 3-month survival and has good stability.
the conclusion that liver cirrhosis is characterized by significant changes in the gut microbiome, with the most significant changes in the ACLF stage of cirrhosis.
changes in the gut microbiome are associated with complications of cirrhosis and survival.
the gut microbiome can lead to disease progression and poor prognosmation.
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