Genes Nutr: The interaction of CDKAL1 rs7747752 polymorphisms with serum L-carnitine and choline levels is associated with an increased risk of gestational diabetes.

Background: With the increasing global prevalence, gestational diabetes mellitus (GDM) has become one of

GDM is a complex disease

Choline, betaine and L-carnitine are important metabolic and nutrient factors, abundant in a variety of foods and play a key role in a variety of physiological processes, such as neurotransmitter synthesis, cell membrane signaling, and lipid transport

Objective: We conducted an age-matched case-control study from a large population-based cohort

Methods: A nested case-control study was conducted on 207 GDM women and their one-to-one age-matched controls from a prospective cohort

Results: CDKAL1 rs7747752 G > C correlated with GDM in additional, dominant, and recessive modes (P<0.

Table 1 The ratio of advantages of low L-carnitine, choline, betaine, and rs7747752 to gestational diabetes

Table 2 Combined effects of RS 7747752 and low L-carnitine, choline and betaine in gestational diabetes

Table 3 Additive interactions of rs7747752 and low L-carnitine and choline in gestational diabetes

Table 4 is used for additive interactions between rs7747752 and hypobetaine in gestational diabetes

Conclusion: CC or CG genotype carriers of CDKAL1 gene rs7747752 have low serum L-carnitine or choline levels and are at high risk of GDM disease

Original source:

Wang H, Li J, Liu J,et al.