Genetic mutations and immune ghosts lead to new coronary disease? Two Science papers reveal new ideas for treatment.

Two papers published online in science, a leading academic journal, reveal the unexpected reasons behind the new coronary disease: more than 10% of the new coronary diseases originate from the "inner ghost" of their own immune systems, and 3.5% of the severe cases are due to specific genetic mutations... Both studies focused on type 1 interferon.
is a pioneer in the fight against viruses, which, when they invade cells, start quickly and locally work, allowing infected cells to produce proteins that can be used to attack the virus.
, type 1 interferons gather nearby immune cells and warn them about cells that are not yet infected.
the first months of the new crown outbreak, scientists wanted to find out if severe illness was linked to a decrease in type 1 interferon.
papers published in the same paper confirmed their hypothesis.
paper, scientists analyzed blood samples from 987 patients with severe neo-crowns.
, 10.2% of patients have an "inner ghost" antibody in their body that attacks, negats, and nedes with type 1 interferons in the patient's body, making them inastive! By comparison, only four of the 1,227 healthy volunteers had similar antibodies in their bodies, or 0.33 percent.
663 people with mild or asymptomatic infections had this necemia antibody.
indicates that at least 10 percent of new coronary diseases are autoimmune attacks on the immune system.
," said Professor Jean-Laurent Casanova, one of the study's co-authors.
is that 94% of patients tested for this insane antibody are male! This extreme gender imbalance has also attracted the attention of scientists.
point out that this may be due to a chain of invisible genetics on some kind of X chromosome.
because women have two X chromosomes, the risk of being affected is low.
this hypothesis, a severely ill female patient has a rare condition and an X chromosome is silenced.
the same internal antibody in her body.
second paper, the scientists took samples from 659 patients with severe illness and 534 patients with mild or asymptomatic conditions and sequenced DNA.
their focus was on 13 genes known to be associated with type 1 interferon synthesis or effectiveness.
, 3.5 percent of severely ill patients had these rare mutations, which were spread across eight of their genes.
blood samples showed that these patients did carry less interferon.
compared to the control group, there were no mutations.
the first paper to link genetic mutations that cause disease to new coronary diseases, the researchers said.
that the two studies are combined and have very important clinical implications.
, they suggest that type 1 interferon may be an important protective molecule.
fact, there are many clinical trials in progress to assess the protective effects of type 1 interferon.
of course, if neutral antibodies are present in the body, or if there is a genetic mutation that invalidates type 1 interferon, the treatment will have a significant impact.
, it also suggests that we should develop an antibody detection tool that tells us which patients have immune systems with immune antibodies.
this allows us to assess patients' prognostics ahead of time.
, it also suggests that we should use "rehabilitation plasma therapy" with caution, as it may contain antibodies to meso-type 1 interferon.
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