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Changes in the composition and function of the intestinal microbiota affect the physiology of the host by affecting metabolism, immunity , aging and behavior
.
The research of intestinal flora is mainly through independent culture methods based on fecal DNA sequencing, such as 16S rRNA gene sequencing or metagenomic sequencing
immunity
Recently, University of Leuven (UCLouvain) researcher Patrice Cani and his team discovered a new kind of bacteria and published the results on GUT
.
The incident originated in 2015.
The research team repeatedly observed that a type of bacteria (called Subdoligranulum) is almost absent in obese and diabetic patients, but systematically exists in healthy people
.
Therefore, they decided to conduct a careful study of this "family" of bacteria
One type of bacteria (called Subdoligranulum) is almost absent in obese and diabetic patients, but it exists systematically in healthy people
Instead, the team discovered a new type of bacteria (the researchers named it Dysosmobacter welbionis).
Dysosmobacter welbionis produces butyrate, which is known to reduce the risk of colon cancer , for example by strengthening the intestinal barrier and improving immunity
.
But the research team also observed that in patients with type 2 diabetes, Dysosmobacter welbionis is low
Colon cancer
By analyzing 12,000 fecal samples (microbiota) from all over the world, the researchers observed that this bacterium is present in 70% of the population
.
The research team then tested the effects of Dysosmobacter welbionis in mice
.
It turned out that this bacteria increases the number of mitochondria, thereby reducing sugar levels and body weight.
It turned out that this bacteria increases the number of mitochondria, thereby reducing sugar levels and body weight.
Dysosmobacter spp is negatively correlated with human BMI
Dysosmobacter spp is negatively correlated with human BMIIn addition, it has also been observed that the effects of this bacteria are not limited to the intestinal tract
.
Scientists have discovered that certain molecules produced by Dysosmobacter welbionis migrate around the body and have long-distance effects
Original source: Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice.
http://dx.
http://dx.
doi.
org/10.
1136/gutjnl-2020-323778 Leave a message here
