Gut: Increased severity and 30-day mortality in patients with acute pancreatitis with SARS-CoV-2 infection

There is growing evidence that the pancreas may be the target organ of the SARS-CoV-2 virus.
recently, Gut, an authoritative journal in the field of digestive diseases, published a study to investigate the outcomes of patients with acute pancreatitis (AP) associated with SARS-CoV-2 infection.
conducted a forward-looking international multi-center cohort study that included patients treated with AP during the current pandemic.
The main outcome indicators of the study were ap severity, and secondary outcome indicators were AP ethonology, admission to intensive care unit (ICU), length of stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure, and 30-day mortality.
researchers compared the two groups of outcomes using multiple Logistic regressions.
between March 1, 2020 and July 23, 2020, the study included 1,777 AP patients.
149 patients (8.3%) were associated with SARS-CoV-2 infection.
, SARS-CoV-2-positive patients were mostly older men and were more likely to develop severe AP and ARDS (p-lt;0.001).
unaljusted analysis showed that SARS-CoV-2-positive AP patients were more likely to need to be admitted to the ICU (OR 5.21, p.lt;0.001), local complications (OR 2.91, p.lt;0.001) and persistent organs Failure (OR is 7.32, p.lt;0.001), lengthening hospital stay (OR 1.89, p.lt;0.001) and 30-day mortality are higher (OR 6.56, p.lt;0.001).
-adjusted analysis showed that SARS-CoV-2 patients were hospitalized longer (OR 1.32, p.lt;0.001), had a higher risk of persistent organ failure (OR 2.77, p.lt;0.003) and had a higher 30-day mortality rate (OR 2.41, p.lt;0.04).
result, AP patients with SARS-CoV-2 infection had an increased risk of severe AP, worse clinical outcomes, longer hospital stays and higher mortality rates of 30 days.