GUT: Infection with the new coronavirus in patients with acute pancreatitis increases the severity of pancreatic disease and mortality for 30 days

Respiratory complications caused by infection with neo-coronavirus (COVID-19) are the most common sequelae to the disease and are the main cause of increased mortality.
Recently, gastrointestinal symptoms caused by neo-coronavirus infections have also been widely reported, as viral-like ACE2 subjects are also expressed in the gastrointestinal tract, including pancreatic bubbles and islet cells, so COVID-19 infections may cause pancreatic injury and acute pancreatitis, or cause an increased risk of inflammatory reactions, organ failure and pancreatic complications, leading to increased morbidity and mortality.
study is a forward-looking international multi-center cohort study that includes patients treated with acute pancreatitis (AP) during the current new coronary pandemic.
result indicator is the severity of the AP.
secondary outcome indicators were AP e morbidity, admission to intensive care unit (ICU), length of stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and differences in 30-day mortality.
study, which lasted from March 1 to July 23, 2020, included 1,777 AP patients.
149 patients (8.3%) were infected with SARS-CoV-2.
, the most positive patients with neo-coronavirus are older men and are more likely to develop severe AP and acute respiratory distress syndrome (ARDS).
patients with SARS-CoV-2-positive APs are more likely to need ICU treatment (OR 5.21, p .lt;0.001), more local complications (OR 2.91, p.lt;0.001), persistent organ failure (OR 7.32, p. 0.001) has a higher rate of occurrence, longer hospital stays (OR 1.89, p.lt;0.001), and an increased mortality rate of 30 days (OR 6.56, p.lt;0.001).
study confirmed an increased risk of severe AP in patients with AP-COVID-19 infection, poorer clinical prognosis, significantly longer hospital stays, and a higher 30-day mortality rate.