Gut: Large-scale eradication of Helicobacter pylori can reduce the incidence and mortality of stomach cancer.

Although guidelines have recommended large-scale eradication of Helicobacter pylori as a means of eliminating stomach cancer, its long-term effects are not yet clear.
A recent study published in Gut, an authoritative journal in the field of digestive diseases, began a large-scale eradication of Helicobacter pylori infection in 2004 for people living in the Mazu Islands who are at high risk of contracting Helicobacter pylori over the age of 30, until 2018.
researchers treated people who tested positive for 13C-urea exhalation and assessed the efficacy of large-scale eradication of Helicobacter pylori in reducing stomach cancer morbidity and mortality, which were investigated until late 2016 and 2018, respectively.
after six rounds of large-scale screening and eradication treatment, the coverage rate of Helicobacter pylori eradication treatment reached 85.5% (6512/7616) and the referral rate of treatment was 93.5% (4286/4584).
prevalence of Helicobacter pylori fell from 64.2% to 15.0%, and the reinserted rate was less than 1%.
and severity of atrophy gastritis and intestinal epidermatitis also decreased over time.
decreased the incidence and mortality of stomach cancer by 53 per cent during chemical prevention compared to the historical control period from 1995 to 2003 (95 per cent CI was 30 to 69 per cent, p?lt;0.001) and 25 per cent (95 per cent CI was -14 to 51 per cent, p-0.18 per cent).
there was no significant change in the occurrence of other digestive tract cancers or the resistance of Helicobacter pylori.
, it can be seen that population-based Helicobacter pylori eradication treatment can significantly reduce the incidence of stomach cancer, but the incidence of adverse outcomes did not increase.
increased follow-up time is likely to result in a decrease in mortality.
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