GUT: Liver function at admission will affect the prognosis of patients with new coronary disease

New Coronavirus-COVID-19 mainly affects the lungs and causes respiratory symptoms, but there are also other organ system involvement phenomena, such as myocarditis, acute kidney injury, nervous system abnormalities, and acute liver injury
.

Up to 76% of patients have abnormal liver biochemical indicators.

New Coronavirus-COVID-19 mainly affects the lungs and causes respiratory symptoms, but there are also other organ system involvement phenomena, such as myocarditis, acute kidney injury, nervous system abnormalities, and acute liver injury

 

To this end, the researchers prospectively included 217 patients with COVID-19 in a university hospital without pre-existing liver disease for analysis to assess the relationship between abnormal LFT and the course of the disease at the time of admission
.

Severe disease progression is defined as admission to an intensive care unit (ICU) or death related to COVID-19

 

This study found that 58% of patients had abnormal LFT at baseline, mainly aspartate aminotransferase (AST) (42%), γ-glutamyltransferase (GGT) (37%) and alanine aminotransferase ( ALT) (27%) is elevated, and 33% of patients have hypoalbuminemia
.

Elevated ALT and GGT and hypoalbuminemia are associated with a higher proportion of patients requiring ICU treatment and mechanical ventilation

Figure: The probability of abnormal liver enzymes and the severity of the new crown

This study confirmed the admission LFT abnormalities, especially GGT and albumin levels are abnormal infection risk factors SARS-CoV-2 virus develop worsening disease
.

This study confirmed the admission LFT abnormalities, especially GGT and albumin levels are abnormal infection risk factors SARS-CoV-2 virus develop worsening disease
.

Infect

 

 

Original source:

Sabine Weber.

Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study.
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