Gut: Mediterranean dietary interventions can change the gut microbiome of older people.

BACKGROUND AND OBJECTIVE: Aging is accompanied by the degradation and inflammation of a variety of body functions, which together lead to infirmity.
previous studies have shown that physical weakness changes with changes in the gut microbiome.
Mediterranean diet (MedDiet) is associated with health.
, the study looked at whether a year-long MedDiet intervention in the NU-AGE project could alter the gut microbiome and improve health.
: The researchers tailored a 12-month MedDiet intervention for older subjects.
before and after the intervention, the researchers analyzed the gut microbiomes of 612 non-infirm or infirm pre-trial subjects in five European countries (Britain, France, the Netherlands, Italy and Poland).
: The results show that sticking to this diet can change a specific microbiome.
increased microbiome as a result of adherence to this diet can elevate several markers that reflect physical and cognitive enhancement and reduce inflammatory markers, including C-reactive proteins and albumin-17.
analysis of microbial metabolites showed that changes in the microbiome of dietary regulation were associated with increased production of short-chain/branch-chain fatty acids and a decrease in the production of methol, ethanol and carbon dioxide.
analysis of the ecosystem network of microbial community shows that the bacterial groups that respond positively to MedDiet intervention occupy the key interaction positions, while the bacteria groups associated with infirmity are on the periphery of the network.
: This study supports the feasibility of improving habitual diets to regulate gut bacteria, which may promote healthier aging in the population.
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