GUT: Non-compliance with colonoscopy after positive stool immunochemical test doubles risk of dying from colorectal cancer

The Fecal Immunochemical Test (FIT) is one of several tests available for colorectal cancer (CRC) screening and is currently used in many countries
.

FIT screening involves two procedures, and clinical guidelines recommend follow-up colonoscopy for FIT-positive participants

The Fecal Immunochemical Test (FIT) is one of several tests available for colorectal cancer (CRC) screening and is currently used in many countries

 

In total, FIT-based CRC screening in the Veneto region of Italy included FIT-positive (>20 µg Hb/g stool) 50- to 69-year-olds, with some patients undergoing diagnostic colonoscopy at endoscopy referral centers
.

In this retrospective cohort study, we used Kaplan-Meier model estimates and Cox models to compare FIT-positive patients who completed a scheduled diagnostic colonoscopy (performers) with those who did not ( 10-year cumulative CRC morbidity and mortality in non-executors

diagnosis

 

Results of the study showed that 88 013 patients with a positive FIT screen followed colonoscopy (male: 56.
1%; 50-59 years: 49.
1%), whereas 23 410 did not comply with further colonoscopy (male: 54.
6%; 50-59 age: 44.
9%)
.

The 10-year cumulative incidence of CRC was 44.

 

This study confirms that the risk of death from CRC is too high in people who have not completed colonoscopy after a positive fecal occult blood test, and should prompt effective interventions in screening programs to improve compliance in this high-risk group
.

This study confirms that the risk of death from CRC is too high in people who have not completed colonoscopy after a positive fecal occult blood test, and should prompt effective interventions in screening programs to improve compliance in this high-risk group
.

Original source:

Manuel Zorzi.

Non-compliance with colonoscopy after a positive faecal immunochemical test doubles the risk of dying from colorectal cancer.
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