HAEMATOLOGICA: Third-hand tobacco exposure regulates platelet function in the uterus in a gender-dependent manner

Third-hand tobacco (THS) is the residue of tobacco smoke that persists after cigarettes are extinguished, and has become a threat to human health in the past decade
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Table 1: Peripheral blood cell counts of male and female mice after exposure to THS and clean air in utero
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Figure 1: In utero THS exposure shortened the bleeding time in the tail bleeding time test and the occlusion time in the thrombosis model in men and women
.

Figure 2: The effect of in-utero THS exposure on platelet physiology in exposed male and female mice compared with a control group exposed to clean air
.

Figure S1: Flow cytometry analysis of platelet activation markers; α granule secretion (P select secretin), GPIIb-IIIa (αIIbβ3) activation and phosphatidylserine (PS) exposure in exposed male and female mice
.

The data provides evidence that the negative health effects of THS exposure to pregnant women extend to "unexposed" offspring
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