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Hemophilia A and Hemophilia B are inherited bleeding disorders caused by the deficiency of factor VIII (FVIII) and factor IX (FIX), respectively
.
Clotting factor replacement surgery isthe main treatment method to prevent and treat bleeding
.
In formulating contemporary priorities for optimizing hemophilia care, it is important to understand the epidemiological changes in the cause of death
.
Many population-based cohort studies report a wide range of standardized mortality (SMR) for PWH compared with the general population
.
Hemophilia A and Hemophilia B are inherited bleeding disorders caused by the deficiency of factor VIII (FVIII) and factor IX (FIX), respectively
.
Clotting factor replacement surgery isthe main treatment method to prevent and treat bleeding
.
Hemophilia A and Hemophilia B are inherited bleeding disorders caused by factor VIII (FVIII) and factor IX (FIX)respectively.
Evaluate the time trends of all-cause and all-cause-specific SMR in PWH over the past few decades
The team conducted a systematic review of the literature based on the meta-analysis guidelines for epidemiological observational studies, and systematically searched the central registry of controlled trials of EMBASE, MEDLINE, Web of Science, CINAHL, and Cochrane from inception to March 15, 2021 Book
.
Of the 4769 studies identified, 52 met the eligibility criteria
.
The pooled all-cause standardized mortality (SMR) of the 9 studies in PWH was 1.
93 (95% CI 1.
2 2 2 heart blood vessels
In summary, it is concluded that with the advancement of treatment, the mortality rate of PWH has declined in the past few decades and is close to the mortality rate of the general population
With the advancement of treatment, the mortality rate of PWH has declined in the past few decades and is close to the mortality rate of the general population.
Original source:
Alam, AUL ,Karkhaneh, M ,Attia, T ,Wu, C ,the Sun, H (L) .
Alam, AUL ,Karkhaneh, M ,Attia, T ,Wu, C ,the Sun, H (L) .
All-the cause is mortality and Causes of Death in persons with Haemophilia: A Systematic Review and Meta-Analysis .
Haemophilia .
2021 ; .
1 - 14 .
https://doi.
org/10.
1111/hae.
14423 in this message
