Heart: How is obesity and weight loss related to heart failure?

This meta-analysis aims to determine the relationship between obesity and heart failure (HF) and the effects of intentional weight loss after bariatric surgery on the heart structure and heart muscle function of obese subjects.
researchers looked at studies published by MEDLINE, Embase, and Web of Science prior to April 3, 2018, that reported the association and prognosory effects of obesity in HF, as well as studies on the effects of intentional weight loss after bariatric surgery on heart structure and cardiomyopathy in obese subjects.
results, the researchers reviewed 4,959 citations.
, 29 studies were analyzed.
analysis showed a 'J-curve' relationship between body mass index (BMI) and HF risk, with pathologically obese people at the greatest risk (1.73 (95% CI 1.30 to 2.31), P.lt;0.001, n=11).
'Obesity Paradox' was observed in all-cause mortality, although hyperrecombination was associated with lower cardiovascular (CV) mortality (OR=0.86 (95% CI 0.79-0.94), n=11), and there was no significant difference between the other BMI groups.
In obese patients who did not identify HF, atrial fibrillation, or known coronary artery diseases, intentional weight loss induced by bariatric surgery was associated with a decrease in left room mass index (p.lt;0.0001), an improvement in left room clement function (p.0.0001) and a decrease in left atrial size (p.02).
, although obesity increases the risk of HF, the 'obesity paradox' arises entirely from mortality.
, however, the lowest CV mortality was observed in hyper-recombination.
, intentional weight loss was associated with improved heart structure and heart muscle function indicators in obese patients.
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