Hyperuricemia harms "+1", or increases the risk of "erectile dysfunction"

Edited by Yimaitong, please do not reprint without authorization
.

Gout is an ancient disease.
It used to occur mostly in emperors, generals, ministers and dignitaries, so it is known as "the disease of wealth"
.

However, with the improvement of living standards, the prevalence of hyperuricemia in China has reached 13.
3%, and the number of patients has reached 180 million
.

Moreover, the harm of hyperuricemia is not limited to gout
.

Recently, a study published in the journal ANDROLOGIA showed that patients with hyperuricemia have a 59% increased risk of erectile dysfunction (ED) compared with the general population, and that receiving uric acid-lowering therapy can reduce the risk of ED
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Hyperuricemia and endothelial dysfunction In humans, serum uric acid can affect endothelial function
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Endothelial dysfunction caused by hyperuricemia is involved in the pathogenesis of cardiovascular disease, and at the same time, endothelial dysfunction is also the main pathogenesis of ED
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To explore the relationship between hyperuricemia and ED, and to further analyze the effect of uric acid-lowering therapy on the risk of ED
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We conducted this systematic review and meta-analysis, including 5 cohort studies and 6 cross-sectional studies related to "hyperuricemia and ED" with a total of 454,510 participants
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Hyperuricemia or substantially increased risk of ED data showed that patients with hyperuricemia had a 1.
59-fold higher risk of developing ED than patients without hyperuricemia (OR=1.
59)
.

Uric acid-lowering therapy reduces the risk of ED by 27% in hyperuricemic patients (OR=1.
27)
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After subgroup analysis, except for the subgroup of ">60 years old", there was a significant correlation between hyperuricemia and ED
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Summary This study suggests that hyperuricemia is an important risk factor for ED, and uric acid-lowering therapy can significantly reduce the risk of ED in patients with hyperuricemia
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Endothelial dysfunction associated with hyperuricemia may underlie the pathogenesis of ED
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Yimaitong compiled and compiled from: Wang W, Jing Z, Liu W, Zhu L, Ren H, Hou X.
Hyperuricaemia is an important risk factor of the erectile dysfunction: A systematic review and meta-analysis[J].
ANDROLOGIA.
2022 Feb 7: e14384.
DOI: 10.
1111/and.
14384, PMID:35130578