Immunity: Xu Chunliang and others found that intestinal flora regulates the inflammation of blood vessels caused by psychological pressure.

Psychological stress is a common psychological activity in daily life, excessive mental stress can have harmful effects on human health, and a variety of human diseases have a positive correlation, especially cardiovascular disease.
these diseases are usually closely related to stress-induced inflammatory responses.
when the body is stimulated by stress, the pressure signals generated by the brain are transmitted to other organs in two main ways: the sympathetic nervous system, SNS, and the hypothalamus-pituitary-adrenal axis (hypothalamic-pituitary-adrenal axis, HPA axis).
SNS is activated to secrete hormones including adrenaline and norepinephrine to regulate the function of the machine.
HPA axis is activated and acts through the adrenal cortex (adrenal cortex) to secrete glucocorticoids.
However, the mechanism by which stress promotes the onset of vascular disease is not clear.
July 30, 2020, the Team of Paul S. Frenette of The Einstein College of Medicine (the first author is Dr. Chunliang Xu) published an article entitled The Gut Microbiome Regulates Psychological-Induced Sit- Ins.
the study showed that excessive mental stress increased intestinal permeability, which in turn caused the intestinal bacteria to overactivate th17 cells, causing the central granulocytes to accumulate in the blood vessels and adhere to the walls of the blood vessels and bind to the red blood cells to form cell groups, leading to blockages in the blood vessels.
In this study, Dr. Xu Chunliang and others used mouse models of sickle cell disease (sickle cell disease, SCD) to study the effects of stress on blood vessel blockages. Pain and organ damage caused by
vascular blockage (Vaso-occlusive episodes, VOE) are the main clinical manifestations of SCD patients. Previous research
Professor Paul Frenette's lab has shown that aged neutrophils mediate the occurrence of VOE.
in this study, Dr. Xu Chunliang and others used the disease model to find that binding stress and repeated social failure stress can promote the occurrence of VOE, suggesting that stress can lead to abnormal seizures of the blood vessel.
mechanism study has found that stress signals can induce aging neutrophils to accumulate in the circulatory system, leading to VOE, and the process relies on intestinal flora and Th17 cells. further research
found that the pressure signals produced by the brain activate the HPA pathway, which causes the latter to secrete glucocorticoids, which increases the permeability of the intestinal wall, leading to the excessive activation of Th17 cells by the gut bacteria SFB, which secretes IL-17, which promotes the production of neutrophils and the aggregation and aging of the circulatory system.
this study is the first to reveal the regulatory effect of intestinal flora on vascular diseases mediated by stress, providing new ideas for the treatment of these diseases.
first author Dr. Xu Chunliang graduated from Shandong University with a bachelor's degree, and then under the guidance of Professor Shi Yuxuan, an expert in immunology and stem cell at the Shanghai Academy of Life Sciences of the Chinese Academy of Sciences, under the guidance of Professor Shi Yuxuan, he was mainly engaged in the study of interstitial stem cells and immune interactions.
postdoctoral training phase under the guidance of bone marrow stem cell authority Professor Paul Frenette, hematopoietic stem cell microenvironment, intestinal flora, nerves and inflammation related to the work.
Dr. Xu Chunliang, who previously worked as a first author in the journals Nature Medicine, Immunity, Nature Communications, Journal of Experimental Medicine (received), Blood and Oncogene, is currently preparing to set up its own laboratory, which will focus on the microenvironment of hematopoietic stem cells, symbiosis, the interaction of the nervous system, and blood diseases, combined with basic research and transformational research.
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