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▎ WuXi AppTec content team editor
Hepatocellular carcinoma is the sixth most common type of cancer worldwide, with more than 900,000 new cases in 2020, and more than two-thirds of patients are already in advanced stages of the disease at the time of diagnosis, with only 7% of advanced patients surviving for more than 5 years
Carellizumab/apatinib reduces risk of disease progression or death by 48%
In this randomized, open-label, international Phase 3 clinical trial, patients with unresectable hepatocellular carcinoma were randomized to receive carellizumab/apatinib or sorafenib
The conference summary showed that the median follow-up time was 7.
In addition, at a median follow-up time of 14.
Efficacy results of carellizumab/apatinib (C+R) (Image source: Reference[2])
The researchers said this result showed that the carrelizumab/apatinib combination significantly prolonged progression-free survival and overall survival in patients with unresectable hepatocellular carcinoma compared with the active control
Terelizumab shows clinically significant overall survival benefit
In a randomized, open-label, phase 3 global clinical trial called RATIONALE-301, patients with unresectable hepatocellular carcinoma were treated
The conference summary showed that the median OS of the terelitizumab group was 15.
9 months at least 33 months of follow-up, and the non-inferiority criterion (HR: 0.
85) was met compared with the control group (14.
1 months).
The objective response rate of Terelizumab was 14.
3%, which was better than that of the active control group (5.
4%)
.
The median duration of remission was 36.
1 months in the terelitizumab group and 11.
0 months
in the control group.
In terms of safety, the proportion of adverse events exceeding grade 3 in the tirelizumab group and the adverse events leading to treatment discontinuation were lower than in the active control group
.
The researchers said this result shows that terelizumab, as a monotherapy, can provide clinically significant overall survival benefits and has better safety profiles
.
More innovative therapies are expected to achieve positive clinical results and bring more treatment options to liver cancer patients
.
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