Industrial EnzymeS - Neglected Bio-Industry "Chip"

"So far, China does not have a completely independent industrial enzyme production expression system does not have a real bulk industrial enzyme gene engineering enzyme industrialization." Ma Yanhe, deputy director of the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences and director of the National Engineering Laboratory of Industrial Enzymes, said somewhat surprisingly
Despite the introduction of various state incentives and policies also frequently shouted to strengthen the development of new industrial enzyme preparations can be domestic enzyme seisy seisped does not seem to have improved
Since China's old enzyme manufacturer Wuxi enzyme preparation factory by foreign-funded enterprises Jenenko income bag, Novozymes and other major international enzyme giants crazy beach beach in the Chinese market local enzyme preparation industry is not difficult to understand the embarrassing situation
In Mayen and it seems that due to China's enzyme preparation production technology level is low, lack of talent, poor product adaptability, high production costs and other reasons domestic enzyme preparation enterprises can not compete with international giants at present
"The enzyme industry is a high-tech industry with a very intensive knowledge, which involves almost all biotechnology such as genes, proteins, cells, fermentation, but it is only regarded as a low value-added industrial product" Mayen said
The lack of core components pinch-fingered enzyme preparation industry in China has been developed for many years can now domestic enzyme preparation products but still to crude products and low-level repetition-based
According to annual statistics, the world's total sales of enzymes amounting to US$100 million in domestic enzymes accountforate of only the low-end varieties of glycosase, amylase, protease and other varieties accounting for about the total amount
As far as the current market situation is concerned, the use of enzyme preparations in China is mainly concentrated in starch or corn deep processing, feed, winemaking and other limited industries for textiles, tanning, paper, degluing, bio-organic synthesis and other fields of new industrial enzyme varieties development efforts are far from enough
In addition, China's enzyme enterprises generally lack market competitiveness in the 1990s domestic enzyme preparation stake in the domestic market share and now less than the profit margin of foreign products generally in the domestic but not
"The important reason for this is that technology research and development has not kept up." Ma Yanhe said that the domestic enzyme preparation production is still basically using the traditional fermentation, separation extraction technology strains are also based on traditional mutagenic screeningAnd foreign countries as early as a year ago has been modern biotechnology into the production of enzymes
In Mayan and it seems that the scale expression system of strong versatility is regarded as the core competitiveness of large international companies can china's enterprises simply can not develop domestic scientific research institutions also have no sustained research and development investment which causes the lack of key technology in China's enzyme industry research and development chain
Foreign monopoly "Our current technical means and research and development team and Jenenko, Novishin and other international giants have no comparability even if it is difficult to surpass their domestic enterprises can not go on to hand over to foreign enterprises to do." In the face of foreign monopoly of domestic enzyme industry, the current situation of Mayan and blunt
As an expert in the field of "planning, Ma Yanhe felt that the root cause of the problems in the enzyme industry in China lies in the lack of independent intellectual property rights and the genetic resources with the prospect of industrial applications, but also lack of the most suitable genetic screening, molecular modification, expression preparation, application performance evaluation and industrialization application of the research and development platform more lack of talent reserves and financial support
According to Ma Yanand revealed that most of the domestic enzyme preparation enterprises are buying foreign strains and expression systems but with foreign excellent performance of enzyme coding genes, efficient expression system and green application process has applied for patent protection of China's intellectual property rights riskist
It is worth emphasizing that because the enzyme industry is a technology-intensive industry requires a lot of research and development investment Take Novozymes, for example, the company's research and development investment in recent years has been maintained in the total sales of the above-year research and development investment equivalent to about 100 million yuan
On the contrary, the amount of money used by our country's enzyme enterprises to develop new products and improve the production process is less than the sales of products
So it seems that the domestic enzyme preparation company's research and development funds are far from sufficient "Most of the domestic capital and talent are concentrated in the biopharmaceutical field of enzymes accounted for a small share In fact, the biological industry in order to make progress the most need to break through is the enzyme preparation Mayen he said
Important EnzymeS Technology InnovationS At present, the world's pure enzyme market size is only a few billion dollars but supports the downstream dozens of times or even hundreds of times the industry
Theoretically, enzyme proteins can degrade and synthesize almost all organic compounds
For this reason, industrial enzymes can be called the emerging biological industry "chip" with dozens of times or even hundreds of times the amplification effect
However, the problem behind the strong market demand can not be ignored because China's enzyme production technology backward too high production costs and energy consumption makes domestic enterprises difficult to bear
The data show that the manufacturing cost of enzyme preparationins in China accounts for sales, while foreign enterprises only account for the profit margin of enterprises lower than the foreign enterprises
In this regard, May Yanhe thinks that china's development of enzyme industry needs to establish a new technology system under the traditional technology has no way to compete with foreign countries
The state should combine the market demand of enzymes in China to strengthen research and development of new technologies for the important enzymes needed in China to solve the key technical problems such as industrial enzyme performance transformation, low-cost production and application development to establish independent property rights of technology and bacteria
At the same time, we should vigorously promote the application of enzymes in the industrial field, especially textile, paper, leather and other high-polluting industries through enzyme-based bio-processes to transform the traditional chemical processing industry to achieve a real industrial upgrading of green production
"So far, China does not have a completely independent industrial enzyme production expression system does not have a real bulk industrial enzyme gene engineering enzyme industrialization." Ma Yanhe, deputy director of the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences and director of the National Engineering Laboratory of Industrial Enzymes, said somewhat surprisingly
Despite the introduction of various state incentives and policies also frequently shouted to strengthen the development of new industrial enzyme preparations can be domestic enzyme seisy seisped does not seem to have improved
Since China's old enzyme manufacturer Wuxi enzyme preparation factory by foreign-funded enterprises Jenenko income bag, Novozymes and other major international enzyme giants crazy beach beach in the Chinese market local enzyme preparation industry is not difficult to understand the embarrassing situation
In Mayen and it seems that due to China's enzyme preparation production technology level is low, lack of talent, poor product adaptability, high production costs and other reasons domestic enzyme preparation enterprises can not compete with international giants at present
"The enzyme industry is a high-tech industry with a very intensive knowledge, which involves almost all biotechnology such as genes, proteins, cells, fermentation, but it is only regarded as a low value-added industrial product " Mayen said
The lack of core components pinch-fingered enzyme preparation industry in China has been developed for many years can now domestic enzyme preparation products but still to crude products and low-level repetition-based
According to annual statistics, the world's total sales of enzymes amounting to US$100 million in domestic enzymes accountforate of only the low-end varieties of glycosase, amylase, protease and other varieties accounting for about the total amount
As far as the current market situation is concerned, the use of enzyme preparations in China is mainly concentrated in starch or corn deep processing, feed, winemaking and other limited industries for textiles, tanning, paper, degluing, bio-organic synthesis and other fields of new industrial enzyme varieties development efforts are far from enough
In addition, China's enzyme enterprises generally lack market competitiveness in the 1990s domestic enzyme preparation stake in the domestic market share and now less than the profit margin of foreign products generally in the domestic but not
"The important reason for this is that technology research and development has not kept up." Ma Yanhe said that the domestic enzyme preparation production is still basically using the traditional fermentation, separation extraction technology strains are also based on traditional mutagenic screening And foreign countries as early as a year ago has been modern biotechnology into the production of enzymes
In Mayan and it seems that the scale expression system of strong versatility is regarded as the core competitiveness of large international companies can china's enterprises simply can not develop domestic scientific research institutions also have no sustained research and development investment which causes the lack of key technology in China's enzyme industry research and development chain
Foreign monopoly "Our current technical means and research and development team and Jenenko, Novishin and other international giants have no comparability even if it is difficult to surpass their domestic enterprises can not go on to hand over to foreign enterprises to do." In the face of foreign monopoly of domestic enzyme industry, the current situation of Mayan and blunt
As an expert in the field of "planning, Ma Yanhe felt that the root cause of the problems in the enzyme industry in China lies in the lack of independent intellectual property rights and the genetic resources with the prospect of industrial applications, but also lack of the most suitable genetic screening, molecular modification, expression preparation, application performance evaluation and industrialization application of the research and development platform more lack of talent reserves and financial support
According to Ma Yanand revealed that most of the domestic enzyme preparation enterprises are buying foreign strains and expression systems but with foreign excellent performance of enzyme coding genes, efficient expression system and green application process has applied for patent protection of China's intellectual property rights riskist
It is worth emphasizing that because the enzyme industry is a technology-intensive industry requires a lot of research and development investment Take Novozymes, for example, the company's research and development investment in recent years has been maintained in the total sales of the above-year research and development investment equivalent to about 100 million yuan
On the contrary, the amount of money used by our country's enzyme enterprises to develop new products and improve the production process is less than the sales of products
So it seems that the domestic enzyme preparation company's research and development funds are far from sufficient "Most of the domestic capital and talent are concentrated in the biopharmaceutical field of enzymes accounted for a small share In fact, the biological industry in order to make progress the most need to break through is the enzyme preparation Mayen he said
Important EnzymeS Technology InnovationS At present, the world's pure enzyme market size is only a few billion dollars but supports the downstream dozens of times or even hundreds of times the industry
Theoretically, enzyme proteins can degrade and synthesize almost all organic compounds
For this reason, industrial enzymes can be called the emerging biological industry "chip" with dozens of times or even hundreds of times the amplification effect
However, the problem behind the strong market demand can not be ignored because China's enzyme production technology backward too high production costs and energy consumption makes domestic enterprises difficult to bear
The data show that the manufacturing cost of enzyme preparationins in China accounts for sales, while foreign enterprises only account for the profit margin of enterprises lower than the foreign enterprises
In this regard, May Yanhe thinks that china's development of enzyme industry needs to establish a new technology system under the traditional technology has no way to compete with foreign countries
The state should combine the market demand of enzymes in China to strengthen research and development of new technologies for the important enzymes needed in China to solve the key technical problems such as industrial enzyme performance transformation, low-cost production and application development to establish independent property rights of technology and bacteria
At the same time, we should vigorously promote the application of enzymes in the industrial field, especially textile, paper, leather and other high-polluting industries through enzyme-based bio-processes to transform the traditional chemical processing industry to achieve a real industrial upgrading of green production
(Lee Hui-hui)