INT J LAB HEMATO: Peripheral granular lymphopenia and malformed leukocytosis as simple prognostic markers for COVID-19

Although most patients with coronavirus disease ( COVID-19 ) have mild symptoms, up to 15% of patients will develop severe pneumonia, and about 5% of patients will develop acute respiratory distress syndrome and/or multiple organ failure
.

There are no proven remedies other than supportive treatment, but the development of prognostic markers can be used in clinical decision-making, such as intubation time and introduction of extracorporeal membrane oxygenation

Although most patients with coronavirus disease ( COVID-19 ) have mild symptoms, up to 15% of patients will develop severe pneumonia, and about 5% of patients will develop acute respiratory distress syndrome and/or multiple organ failure

Recently, foreign research teams have carried out related studies to evaluate whether investigating PB examinations can predict the prognosis of coronavirus disease (COVID-19)
.

Related results were published in the International Journal of Laboratory Hematology magazine

Recently, foreign research team carried out research, assessment assessment assessment survey to check whether PB can predict coronavirus disease (COVID-19) prognostic investigation to check whether PB can predict the prognosis of coronavirus disease (COVID-19) of

Study of38 is embodiment healthy controls (the HC S ) and 40 new cases of viral pneumonia crown patients (COVID-19) for a complete blood count (CBC) and PB morphological examination

Among COVID-19 patients, the critically ill group showed significantly higher levels of WBC, neutrophil count, NLR, immature granulocytes, RDW-SD and CRP
.

In addition, the lymphocyte count, active lymphocytes, Hb and PLT levels of the severe group were significantly lower than those of the mild group (P <.

Among COVID-19 patients, the critically ill group showed significantly higher levels of WBC, neutrophil count, NLR, immature granulocytes, RDW-SD and CRP

Morphological changes of blood cells in COVID-19 patients and healthy controls

Morphological changes of blood cells in COVID-19 patients and healthy controls Morphological changes of blood cells in COVID-19 patients and healthy controls

Granular lymphocytes are associated with the severity of COVID-19

Granular lymphocytes are associated with the severity of COVID-19

Compared with mild cases, the incidence of anemia, lymphopenia and leukocytosis was significantly higher in severe cases ( P<.
001)
.

In mild cases, the granular lymphocyte count is normal or higher, while in fatal cases it continues to decline

Compared with mild cases, the incidence of anemia, lymphopenia and leukocytosis was significantly higher in severe cases ( P P<.

In summary, studies have shown that by detecting multi-lineage changes in blood cell counts and morphological abnormalities caused by SARS-CoV-2 infection, basic PB examination can be used to predict the prognosis of COVID-19

 

Original source :

Original source Original source :：

Horiuchi Y, Hayashi F, Iwasaki Y, Matsuzaki A, Nishibe K, Kaniyu K, Marutani S, Saito K, Matsuoka S, Uchihashi K, Miida T, Ai T, Tabe Y.

Horiuchi Y, Hayashi F, Iwasaki Y, Matsuzaki A, Nishibe K, Kaniyu K, Marutani S, Saito K, Matsuoka S, Uchihashi K, Miida T, Ai T, Tabe Y.
Peripheral granular lymphocytopenia and dysmorphic leukocytosis as simple prognostic markers in COVID-19.
Int J Lab Hematol.
2021 Sep 15.
doi: 10.
1111/ijlh.
13696.
Epub ahead of print.
PMID: 34523805.
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