Iron deficiency in middle age increases the risk of heart disease

Sophia Antipolis (Sophia Antipolis), October 6, 2021: A study published today in the European Society of Cardiology (ESC) journal ESC heart Approximately 10% of new coronary heart disease cases that occurred during the year can be avoided by preventing iron deficiency

"This is an observational study, and we cannot conclude that iron deficiency causes heart disease," said study author Dr.

Previous studies have shown that in patients with cardiovascular diseases such as heart failure, iron deficiency can lead to worse outcomes, including hospitalization and death

The current study aims to examine whether the association between iron deficiency and prognosis is also observed in the general population

The study included 12,164 people from three European population cohorts

Participants are divided into iron deficiency or iron deficiency according to two definitions: 1) Absolute iron deficiency, which only includes stored iron (ferritin); 2) Functional iron deficiency, which includes stored iron (ferritin) and used for body circulation Iron (transferrin)

Dr.

The subjects were followed up for coronary heart disease and stroke, cardiovascular disease deaths and all-cause deaths

At baseline, 60% of participants had absolute iron deficiency and 64% had functional iron deficiency

Compared with non-functional iron deficiency, the risk of coronary heart disease increased by 24%, the risk of cardiovascular death increased by 26%, and the risk of all-cause death increased by 12%

The researchers calculated the population attribution ratio, which is the proportion of events that can be avoided in 10 years if everyone is at baseline risk of not being iron-deficient

Dr.

Dr.

Dr.

DOI

10.