A new study published a few days ago in the European Society of Cardiology (ESC) journal "ESC Heart Failure" shows that about 10% of coronary heart disease that occurs in middle age can be avoided by preventing iron deficiency
"This is an observational study.
Previous studies have shown that for patients with cardiovascular diseases such as heart failure, iron deficiency can lead to worse outcomes, including hospitalization and death
The current study aims to examine whether an association between iron deficiency and prognosis is also observed in the general population
Participants were divided into two situations: absolute iron deficiency, including only stored iron (ferritin); functional iron deficiency, including stored iron (ferritin) and iron (transferrin) for the body to recycle
Schrage explained: “Absolute iron deficiency is a traditional method for assessing iron status, but it ignores circulating iron
Afterwards, they followed up the participants for coronary heart disease and stroke, death from cardiovascular disease, and all-cause death
At the baseline examination, 60% of participants had absolute iron deficiency and 64% had functional iron deficiency
Compared with non-functional iron deficiency, the risk of coronary heart disease increased by 24%, the risk of cardiovascular death increased by 26%, and the risk of death from all causes increased by 12%
The researchers calculated the population attribution ratio and adjusted the model based on factors such as age, gender, smoking, cholesterol, blood pressure, diabetes, body mass index, and inflammation, and found that 5.
"This study shows that iron deficiency is very common in middle-aged people.
Schrage said that in the future these associations should be studied in young people and non-European populations
Related paper information: https://doi.
https://doi.
org/10.
1002/ehf2.
13589
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