Is Li Ka-shing's superstitious "life-long medicine" a medical miracle or a cut?

Some things are popular for a while, some things are popular for a lifetime.
popular, such as the recent emergence of "Versailles" literature;
2017, Li Ka-shing has publicly expressed interest in a health care product in the media.
Li Ka-shing (youtube video screenshot) would have said this if there had been a Versailles: after using this NR health care product, he felt like he was 20 years old.
said to the secretary: Buy it! As a result, the secretary paid $25 million for a company.
is unique, early last year, Pan Shiyi also sent a tweet: "I never believe in health care products."
, a month ago, a professor at the Massachusetts Institute of Technology recommended me a long-term fairy that their school had studied, which was not yet on the market.
I asked him how he felt after eating, and he said his nails were growing faster after eating.
I ate for nearly a month, had no reaction, and found that my nails were growing very fast.
" this tweet is also some kind of NR health care product.
is the real person who called "the medicine of never getting old"? The health care product, called NR (niacinamide kerucleose), is essentially the same as the now-hot NMN (niacinamide mononucleotides) on social media, but is easier to absorb and the NR when it enters the cell becomes NMN.
2013, The David Sinclair team at Harvard University published a paper in Cell that showed that NMN can be converted into NAD-plus (coenzyme I) in the body.
: Cell in the human body, NAD plus is a coenzyme of hundreds of important metabolic enzymes, and as a signaling molecule involved in many important activities in cells, and energy metabolism, sugar enzymes, DNA replication and other processes are closely related.
can also be converted from other vitamins B3 (niacin, niacin), although less efficient.
, NMN, NR, and NAD can all be considered vitamin B3 health supplements.
the study, The David Sinclair team used NMN to feed 22-month-old mice for a week and then examined indicators such as mitochondrial stability and muscle health in mice and found that they returned to a six-month level.
Over the next few years, the David Sinclair team written back-to-back articles that NMN therapy could improve the ability of mouse cells to repair DNA damage, increase capillaries density for SIRT1 dependence, improve blood flow and increase endurance in older mice.
: Science is also the study that opened up the "myth" of NMN's longevity.
but it's obviously not that simple.
most important question in the world is: How do you assess whether this "Sendan" can really extend its life? For one thing, the rich seem to have overlooked the important fact that the protagonists of these studies are still rats.
the metabolism of humans and animals, the effects of the same drug will be very different.
no drug can be approved for the treatment of human diseases based on animal test results alone.
study by the David Sinclair team, mice needed to be given oral NMN at a dose of 2g/kg to improve their ability to repair DNA damage.
Even if we assume that taking at this dose is effective for the human body, it is obviously impossible for an adult weighing 50 kg to take 100 grams of NMN per day - about 300 mg per day, as indicated in the packaging of such health products.
Li Ka-shing claims to be taking health care products second, from the outcome indicators, the beginning of this article "user experience" is also not feasible, for example, Li Ka-shing said after eating health care products "as if back to 20 years old", Pan Shiyi said that "nails seem to have become longer", relying solely on subjective feelings can not prove the effectiveness of a drug.
might say that a controlled trial doesn't know: one group doesn't eat NMN, one group doesn't eat NMN, and if people who eat NMN live longer on average, it works.
sounds simple, but it's difficult to actually do.
first, the average life expectancy for healthy people is 70 to 80 years, and even looking for an older person to do the experiment will require recruiting a lot of people and doing it for many years.
li Ka-shing, his health care products cost 1.5 million yuan a year to take, and if clinical trials are to be conducted, who will pay for them? In the NMN and NR clinical trials, which have published results so far, no trials have been conducted using "longevity" as an indicator, and most of the trials that have improved function have used some of the more local indicators, such as cognitive function, mood, sleep, etc.
more importantly, although some bio-chemical indicators have changed for trials that have so far reported results, there is no clear evidence of improvement in certain functions.
tell a story or do research? In addition to effectiveness, you have to pay attention to security.
year, Japan announced the results of a clinical trial.
this is a clinical Phase I trial that evaluates the safety of NMN.
only 10 subjects in the entire trial, taking NMN or so only once.
: Endocrine Journal results show that after a single oral 100, 250, or 500 mg NMN, there were no significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
However, biotransformation indicator test results showed a significant increase (53%) increase in serum bilibromolytin levels after oral single dose NMN, and a slight decrease in serum creatinine, chloride and blood sugar levels, although these indicators were still within the normal range.
the test take NMN, the blood test began, but the blood did not detect NMN, but found NMN degradation products.
this is also expected, because NMN is very prone to degradation, degradation occurs before absorption.
the authors, this early clinical trial showed that it was safe for healthy men to take NMN alone.
but this was only a trial, and the subjects in the study took NMN only once, and the safety and effectiveness of long-term use needed further test validation.
but then again, if you can already sell health care products to make money, who would be willing to burn money to seriously do a clinical trial? Selling good health care products is often enough as long as you can tell a good story.
's the story coming from? From the animal experiment data.
example of this is resveratrol.
david Sinclair lab at NMN and has previously studied the life-extending effects of resveratrol.
, believes resveratrol activates a class of proteins called Srtuin, which could theoretically slow aging.
2006, the Sinclair team published research showing that resveratrol can extend the lifespan of mice on a high-calorie diet.
: Nature, Sinclair co-founded a company called Sirtris.
2008, the company was acquired by international pharmaceutical giant GlaxoSmithKline for $720 million.
but after just two years, GlaxoSmithKline stopped research because the project failed, and all investments were lost.
international pharmaceutical giants see a wide range of rich and rich atmosphere, will turn the car here, the general consumer is even more inevitable.
wealth is the real recipe for the rich, and life expectancy has been steadily increasing, according Chinese World Health Organization.
in 2016, life expectancy for newborn male babies was 75 years and for women 78 years.
, in the 1960s, Chinese life expectancy at birth was less than 50 years.
of life expectancy in modern society is not built up by health products, but by state investment in public health and medical resources.
data show that in Europe a hundred years ago, although the overall life expectancy was less than 50 years, the European aristocracy was able to reach the age of 70.
in a sense, money does extend life.
the rich spend more on health care products and more on drugs and treatment.
May 2020, "Macau gambling king" Ho Hongxuan died at the age of 98.
from his illness in 2009 to his death, gambling kings spent more than HK$1.5 billion over 11 years.
his hospital stay, the gambling king directly enculsted in two separate wards in building 37 of the Inpatient Department, at a daily medical cost of about $860,000.
his rest and recuperation home was also equipped with medical equipment to complement his weekday care work and cost at least HK$20 million to buy.
In addition, He Jiali hired 8 famous medical treatment, gambling king every organ, brain, heart, liver, spleen, lungs, kidneys each have a dedicated doctor responsible for: including brain medicine doctor Xie Shengsheng as the primary doctor, in addition to endocrinologist and glycology doctor Yu Huici, cardiologist Dai Youding, respiratory doctor Lai Qiwei, nephrologist Li Fuqiang, Professor of Microbiology, Hong Kong University.
experts from Japan and the United States came to Hong Kong to treat him, and the huge medical team closely monitored all aspects of the gambling king's body.
can live to 98 years old, money is the gambling king's perennity medicine.
youtube video screenshots) but don't look at Li Ka-shing buying health care products spent a lot of money, people have invested a lot in scientific research.
Among this year's Nobel laureates, Horton, a medical award winner, is director of the Li Ka-shing Institute for Applied Virology at the University of Alberta in Canada, and Downer, a chemistry-winning biologist, and Professor of Biomedical and Health Sciences at the University of California, Berkeley.
Li Ka-shing should have donated a lot of money to these schools and research institutes.
to find long-term life, can only be the ceremony of the rich, sincere spirit.
Li Ka-shing spent millions to eat health care products, useful is good, no use of the problem is not big, economic costs for him, just like we ate an more bowl of rice, for ordinary people can be different.
for the general eating melon masses, to eat melon mood to see the rich eat health care products.
smoking cessation limit alcohol, moderate exercise, a balanced diet, than any health care products are useful.
: This article was wrested by Yan Lianmei, former pharmacist of Beijing Harmony Hospital, Pharmacy Director of Harmony Rehabilitation Hospital, Master of Pharmacy, Concord Medical University of China, and professional review references: . . . Gomes, A.P., et al., Declineing NAD (?) induces a pseudohypoxic state-of-the-art nuclear-mitochondrial communication. Cell, 2013. 155 (7): p. 1624-38. [2] Li, J., et al., A conserved NAD (-) binding pocket that regulates protein-protein interactions when aging. Science, 2017. 355 (6331): p. 1312-1317. [3] Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Trevino-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu Le, Turner N, Arany Z, Guarrente L, Sinclair Ings of an Endothelial NAD (-H2S Signaling Network Is a Reversible Cause ofVascular Aging. Cell. 2018;173 (1):74-89 e20. [4] Radenkovic, D. and E. Verdin, Clinical Evidence for Targeting NADally. Pharmaceuticals, 2020. 13 (9): p. 247. Irie, J., et al., Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine Journal, 2020. 67 (2): p. 153-160. [6] Baur, J.A., et al., Resvertrol improves health health and survival of mice on high-calorie