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On August 16, 2021, Enanta Pharmaceuticals announced that the phase 1 clinical trial of EDP-721 has completed the first administration
Hepatitis B is a viral infection that attacks the liver and can cause acute and chronic diseases
EDP-721 is a selective inhibitor of atypical polyadenylic acid polymerases PAPD5 and PAPD7.
▲EDP-721 reduced HBsAg levels by 3 log10 IU/mL in animal models (picture source: Enanta Pharmaceuticals official website)
This two-part phase 1a/b trial will initially evaluate the safety, tolerability, and pharmacokinetics of EDP-721 in healthy volunteers as a single dose and multiple incremental oral administrations
▲The combination of nucleoside analogues, EDP-514, and EDP-721 constitutes a full oral therapy that has the potential to functionally cure hepatitis B (picture source: Enanta Pharmaceuticals official website)
Reference materials:
[1] Enanta Pharmaceuticals Doses First Subject in a Phase 1 Clinical Study of EDP-721, Its Oral Hepatitis B Virus RNA Destabilizer.
(The original text has been deleted)