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J Allergy Clin Immunol: Efficacy and safety of omalizumab in the treatment of nasal polyposis: 2 randomized phase 3 trials

 Last Update: 2021-08-03
 Source: Internet
 Author: User

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Chronic rhinitis with nasal polyps (CRSwNP) is characterized by excessive IgE secretion and eosinophil inflammation

Adult patients with CRSwNP and insufficient response to intranasal corticosteroids were randomly (1:1) assigned to omalizumab or placebo and oral mometasone for 24 weeks

The results showed that patients with POLYP 1 (n = 138) and POLYP 2 (n = 127) showed severe CRSwNP and significant quality of life impairment, with an average NPS higher than 6, and a SNOT-22 score of about 60

In summary, omalizumab significantly improved the endoscopic, clinical and patient-reported results of severe CRSwNP with insufficient response to intranasal corticosteroids, and it was well tolerated

Original source:

Philippe Gevaert, Theodore A Omachi, et al.

Efficacy and safety of omalizumab in nasal polyposis : 2 randomized phase 3 trials

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