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J Allergy Clin Immunol: Study Reveals Molecular Mechanism of Spesolimab in the Treatment of Pustular Psoriasis

 Last Update: 2022-05-19
 Source: Internet
 Author: User

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The IL-36 pathway plays a key role in the pathogenesis of generalized pustular psoriasis (GPP)

Investigators collected pre- and post-treatment skin and blood samples from GPP patients enrolled in a single-arm phase I study (n = 7)

immunity

As a result, 1287 transcripts were up- or down-regulated in GPP and PPP lesions

Taken together, our findings suggest that in GPP patients, spesolimab intervention rapidly modulates dysregulated molecular pathways commonly seen in GPP and PPP patients, which may be related to its ability to improve clinical outcomes in these patients

Original source:

Patrick Baum, et al.

Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasisLeave

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