J Clin Gastroenterol: Probiotic yogurt prevents antibiotic-related diarrhea in adults.

Diarrhea after antibiotic use is a common clinical problem.
role of probiotics in preventing AAD in hospitalized adults remains unclear.
study, which aims to assess the preventive effects of probiotic-supplemented yogurt on antibiotic-related diarrhea (AAD) in hospitalized patients, was published online in J Clin Gastroenterol.
randomized, double-blind, placebo-controlled clinical trials were included in inpatients who began receiving antibiotic treatment.
patients were randomly grouped (2:2:1) and received 200 mL of placebo yogurt per day (streptococcus and Bulgarian Lactobacillus subseor), 200 mL probiotic yogurt (previously plus Lactobacillus acidophilus) La-5, animal Bifidobacteria Lactobacillus Bb-12 and Lc-01, a subseed of Cedric, or do not drink yogurt within 48 hours of starting antibiotic treatment and 5 days after antibiotic suspension (no blind control).
follow-up of patients for 1 month to determine the occurrence of diarrhoea.
results, the study included 314 patients with an average age of 76.
diarrhea rate in the probiotic group was 23.0%, compared with 17.6% in the placebo group, and the absolute risk was reduced by -5.35% (95% confidence interval, -15.4% to 4.7% ;P to 0.30).
diarrhea rates were similar to 20.9% vs. 20.2% ;P -0.91, respectively) in the non-blind control group and the blind method study.
duration of diarrhea, maximum number of detops, or prolonged hospitalization due to diarrhea were no different between groups.
there was no difference in mortality across the groups.
, the results showed that the combined probiotic strains LA-5, BB-12 and LC-01 had no effect on the prevention of AAD in hospitalized patients.
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