J Clin Invest: Decreased oxygenation of adipose tissue is associated with insulin resistance in obese patients

Animal model research data show that the reduction of adipose tissue (AT) oxygenation is involved in the pathogenesis of insulin resistance caused by obesity.

According to fat and insulin sensitivity, the researchers rigorously stratified the participants: metabolically healthy lean participants (MHL; n = 11), metabolically healthy obese participants (MHO; n = 15), and metabolically unhealthy participants Of obese participants (MUO; n = 20), assessed subcutaneous AT partial pressure (pO2), liver and systemic insulin sensitivity, AT expression of genes and pathways involved in inflammation, fibrosis, and branched chain amino acid (BCAA) breakdown , Systemic markers of inflammation, and plasma BCAA concentration.

The results showed that pO2 gradually decreased from MHL to MHO to MUO group, and was positively correlated with insulin sensitivity in the liver and the whole body.

In summary, the results of this study support the view that reduced AT oxygenation in obese people promotes insulin resistance by increasing plasma PAI-1 concentration and reducing AT BCAA decomposition, thereby increasing plasma BCAA concentration.

Original source:

ncbi.