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    Home > Active Ingredient News > Blood System > J Clin Oncol: Efficacy and safety of nasoprilumab in the treatment of hematopoietic stem cell transplantation-associated thrombotic microangiopathy

    J Clin Oncol: Efficacy and safety of nasoprilumab in the treatment of hematopoietic stem cell transplantation-associated thrombotic microangiopathy

    • Last Update: 2022-05-21
    • Source: Internet
    • Author: User
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    Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a serious complication of hematopoietic stem cell transplantation with a high mortality rate and no approved treatment


    Nasoplimab (OMS721) is a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor developed for the treatment of HSCT-TMA


    This study is a single-arm, open-label, flight trial to evaluate the safety and efficacy of nasoprilumab in adult patients with HSCT-TMA


    A single-arm, open-label flight trial to evaluate the safety and efficacy of nasoprilumab in adult patients with HSCT-TMA


    Patients were recruited with any of the following three TMAs: atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, or HSCT-TMA


    A total of 28 patients were recruited and received at least one dose of nasoprilumab (Master Analysis Set [FAS])


    The overall response rate was 61% The overall response rate was 61%



    74% of the total population achieved organ function improvement 74% of the total population achieved organ function improvement



    Nasoprilumab has good safety in patients with HSCT-TMA, and can significantly improve the remission rate and prolong overall survival


    Original source:

    Original Source: Original Source:

    Samer K.


    Samer K.
    Khaled, et al.
    Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation–Associated Thrombotic Microangiopathy.
    Journal of Clinical Oncology.
    April 20, 2022.
    https: //ascopubs.
    org/doi/full/10.
    1200/JCO.
    21.
    02389

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