J Dent Res: Fundamental differences in gum immune cell function may lead to increased risk and severity of PD in T2D subjects

Periodontitis (PD) is a common source of uncontrollable inflammation in obesity-related type 2 diabetes (T2D)PD significantly promotes inflammation of T2D and is associated with poor blood sugar control and increased incidence of T2DNew treatments are urgently needed to combat the sources of periodontal infection and inflammation in T2D patients, which accelerate the onset infection and inflammation in T2D patientsexact mechanism of the relationship between PD and T2D is still unclearEach major immune cell subgroup is associated with unresolved inflammation of PD, whether the host is metabolically healthy or notHowever, the analysis of inflammatory cells in PD and human periodontal tissue is generally focused on mRNA quantification and immunohistitisanalysi analysis, both of which provide limited information on immune cell functionin this study, the researchers used a flow cytometer to determine a combination of cell surface markers and enzymatic immune blotting to assess the distribution and function of immune cells isolated from PD-a-systemic diseases, PD and TD(PD/T2D), or from the gums of oral and systemic health peopleresults showed that in all groups, T-cell subgroups dominated the cellular immune zone of the gums and B cells were relatively smallAlthough the frequencies of immune cells were similar between groups, compared to individual PD/T2D samples, the proportion of CD11b plus or CD4-plus cells secreted in the Cells of IFN/IL-10 or IL-8 was higher compared to the individual PD/T2D samples, the results show that fundamental differences in the function of gum immune cells in PD and T2D subjects may lead to an increase in the risk and severity of PD in T2D subjectsThis difference may indicate a therapeutic target for reducing periodontal inflammation in T2D patients