J Diabetes Res: Study on the key active ingredients and pharmacological mechanism of Tangshen Recipe in the treatment of diabetic nephropathy

Diabetic nephropathy (DN) is a common and serious micro diabetes (DM) vascular complication, is the main cause of end-stage renal disease (ESRD) is an important factor for diabetes morbidity and mortality
.

According to epidemiological evidence, about 15-40% of diabetic patients can worsen to DN

Diabetic vascular major cause of end stage renal disease (with ESRD) is a major cause of end stage renal disease (with ESRD) of

Current studies believe that the occurrence and development of DN is mainly related to metabolic disorders (abnormal lipid metabolism, glucose metabolism disorders, etc.
), protein kinase C activation, oxidative stress, inflammation, hemodynamic changes, and genetic factors
.

Existing drug therapy is mainly to control hyperglycemia and hypertension, such as angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists (ACEI/ARB)

These drugs cannot prevent DN from continuing to develop.

Chinese herbal medicine Multi-component, multi-target, multi-pathway and synergistic effect of Chinese herbal medicine Multi-component, multi -target, multi-pathway and synergistic effect

A recent study published in the Journal of Diabetes Research, used network pharmacology to study the key active components of TSF in the treatment of DN and their pharmacological mechanism , and explore the biologically active components of TSF on DN and the overall potential mechanism
.

Key active ingredients and their pharmacological mechanism of actionKey active ingredients and their pharmacological mechanism of action

The results show that TSF treatment of DN has the characteristics of multiple components, multiple targets, multiple pathways and synergy
.

Quercetin, naringenin, kaempferol, and isorhamnetin are the key active compounds, PI3K-Akt signaling pathway, TNF signaling pathway, non-alcoholic fatty liver (NAFLD) signaling pathway, local adhesion, rap1 signaling pathway, T cell Receptor signaling pathway, MAPK signaling pathway, and insulin resistance are the key molecular mechanisms of TSF treatment of DN, and they play an important role in TSF treatment of DN

Quercetin, naringenin, mountain phenol, isorhamnetin quercetin, naringenin, mountain phenol, Isorhmnetin non-alcoholic fatty liver key molecular mechanisms of key molecular mechanism

references:

references:

[1]Weie Zhou, Xuefeng Zhou, Yuan Zhang,et al.

[1]Weie Zhou, Xuefeng Zhou, Yuan Zhang,et al.
A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy.
Journal of Diabetes Research.
vol.
2021, Article ID 8833688 , 17 pages, 2021.
https://doi.
org/10.
1155/2021/8833688 Leave a message here