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Pain is the most painful symptom of relapsed acute pancreatitis (RAP) and chronic pancreatitis (CP), often treated with chronic opioids or total pancreatic excision and islet self-transplantation, and pain is a complex nerve Signals, including pain signals from injured organs, physiological and pathological reflexes, and advanced brain responses to emotional and related areas (gray areas around the forehead, limbic system, and mid-brain catheters), can exacerbate pain and vice versa.
people with depression tend to have a higher inflammatory immune response;
, some RAP/CP patients who are genetically susceptible to depression may also be susceptible to inflammation and more severe pain.
study explores whether genes associated with depression are associated with persistent severe pain experiences in RAP/CP patients.
researchers conducted a retrospective study of genotype RAP and CP patients in the North American Pancreatitis Study II (NAPS2) queue, with a total of 1,357 people.
subjects were divided into constant severe pain (n s 787) and non-constant severe pain (n s 570) according to the pattern of pain and the severity of the pain, and then a genome-wide association study was conducted.
results showed that 58% of patients with pancreatitis (n s 787) experienced persistent and severe pain.
no difference in sex or alcohol consumption was found, depending on the severity of the pain.
reported a 28% use of antidepressants (n s 223) and their SF-12 psychological quality of life was low (MCS, p.lt;2.2×10-16).
found that 15 gene base (p .lt;00001) associated with persistent severe pain were found to be in or near depression-related genes, including ROBO2, CTNND2, SGCZ, CNTN5, and BAIAP2.
reaction to the use of three antidepressants in these genes (SGCZ, ROBO2, and CTNND2).
depression is a major supporting factor in pain experiences.
screening for this genetic susceptivity to depression may be useful in treating pain in patients with pancreatitis with early antidepressants.
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