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J HEPATOLOGY: Liver fatty acid binding protein (L-FABP) in urine is a prognostic biomarker of chronic liver failure and mortality in patients with decompensated cirrhosis

 Last Update: 2021-10-09
 Source: Internet
 Author: User

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Fatty acid binding protein (FABP) is a group of intracellular chaperone molecules involved in lipid-mediated processes
.

FABPs are considered to be key mediators of metabolic and inflammatory pathways

Fatty acid binding protein (FABP) is a group of intracellular chaperone molecules involved in lipid-mediated processes

The researchers divided the prospective cohort of 444 patients hospitalized with DC into a study cohort (305 patients) and a verification cohort (139 patients)
.

L-FABP was measured in urine and plasma samples collected on admission

In univariate analysis, L-FABP in urine rather than plasma was associated with the 3-month survival rate of DC patients
.

In multivariate analysis, uL-FABP and the end-stage liver disease sodium model (MELDNa) are the only independent predictors of prognosis

This study confirmed that in terms of mortality and ACLF development, UL-FABP levels are independently related to the 3-month clinical course of DC patients
.

If the urine L-FABP and MELDNa scores are combined, it seems to be a better biomarker candidate for DC prognosis prediction

This study confirmed that in terms of mortality and ACLF development, UL-FABP levels are independently related to the 3-month clinical course of DC patients

Original source:

Adrià Juanola.

Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis.
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